The Use of Cell-Based Assays for Translational Medicine Studies

Cell-based assays are an important tool in drug development. One of the biggest challenges when developing a drug is mimicking the appropriate physiological setting to predict the mechanism of action and safety profile when a drug is administered in vivo. However, appropriately designed cell-based assays can provide a solution for this by recreating the key components of […]

ADCC and CDC Assay: Validation and Optimization

ADCC Antibody dependent cellular cytotoxicity (ADCC) is a mechanism in host immune defense where antibodies bind to an antigen on the surface of a cell, targeting that cell for killing by an immune effector cell, such as a Natural Killer Cell (NK cell). The effector cell “recognizes” the antibody bound cell by binding to the […]

Origins of CRISPR: How it Came to Be

Gene editing isn’t a new concept and has been around for decades. In its infancy, gene editing was time-consuming, inaccurate and costly. That all changed when a revolutionary technique called CRISPR took the science community by storm and has since made the process more affordable, efficient and accurate.  CRISPR (Clustered Regularly Interspaced Short Palindromic Repeat) […]

BioAgilytix Adds Extensive Capabilities with the Acquisition of MicroConstants and 360biolabs

BioAgilytix, a leading global contract research laboratory focused on supporting its pharmaceutical and biotech partners in all stages of large molecule drug development, recently acquired MicroConstants and 360biolabs. These acquisitions greatly expand the already impressive scope of BioAgilytix’s capabilities, scientific expertise and geographic footprint.  As an independent bioanalytical testing industry leader, MicroConstants, now known as […]

Plaque Reduction Neutralization Tests (PRNT) and the Development of New Antiviral Drugs

While infectious disease has always been an important area of scientific and medical research, the recent pandemic has brought this discipline more clearly into the public eye. Understanding which infectious agents are currently of concern to global health and which will become a threat in the future is a complicated and serious undertaking within the […]

What Parameters Are Acquired from a PK Study?

The term “Pharmacokinetics” is derived from “pharmakon” and “kinetikos” in ancient Greek, meaning “drug” and “position in motion,” respectively. It is one of the principal assessments in the drug development process that describes what the body does to an administered drug substance and is essential data for defining safe and effective levels of drug to […]

The Broad Array of Vaccine Options for COVID-19

As we pass the two-year anniversary of the start of the coronavirus pandemic, we are reminded of where we started and how far we have come. From day one, we have been able to witness scientific advancements on the world stage as the scientific community quickly came together to address this international health crisis. Through […]

Validation of qPCR Assays for Gene Therapy

Though the modern world has progressed a lot in terms of medical interventions and biomedicine, there still are a vast number of diseases and disorders that demand a rather unconventional approach to treatment. Gene therapy has evolved as a technique that aims to address some of these diseases by introducing into a patient a normal […]

BioAgilytix Adds Extensive Capabilities with the Acquisition of MicroConstants and 360biolabs®️

BioAgilytix, a leading global contract research organization focused on supporting its pharmaceutical and biotech partners in all stages of drug development, recently acquired MicroConstants and 360biolabs®️. These acquisitions greatly expand the already impressive scope of BioAgilytix’s capabilities, scientific expertise and geographic footprint. As an independent bioanalytical testing industry leader, MicroConstants, now known as BioAgilytix San […]

Flow Cytometry in Bioanalysis: Application, Utility and Recent Advancements

Flow Cytometry in Drug Development Flow cytometry is a technique that is used to analyze multiple characteristics of single cells. These characteristics include cell size, cytoplasmic complexity of the cell, as well as expression of cell surface and intracellular proteins. This unique technology utilizes fluidics, optics, and electronic components to interrogate each cell by lasers […]