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Biomarker: αGST

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Analyte:

αGST

Platform:

Matrix:

Rat Urine

Disease State:

Toxicity

Status:

Experienced Running

Required Sample Volume:

25 µL/well

Sensitivity-LLOQ/ULOQ:

LLOQ: 6.0 ng/mL
ULOQ: 1,470 ng/mL

Biological or Clinical Significance:

Alpha Glutathione S-Transferase (αGST) is a detoxification enzyme that catalyzes the conjugation of glutathione with a variety of endogenous and exogenous toxins. This enzyme is part of a mammalian GST super-family consisting of cytosolic dimeric isoenzymes that have been assigned to at least 6 classes: Alpha, Mu, Pi, Theta, Zeta and Omega. Urinary αGST levels are a specific indicator of proximal tubular function and injury. Typically, normal/healthy urine does not contain measurable amounts of αGST, whereas elevated levels correlate closely with the time course and severity of renal injury.

References:

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