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Biomarker: Acid Phosphatase

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Acid Phosphatase



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Biological or Clinical Significance:

Acid phosphatase is a phosphatase, a type of enzyme, used to free attached phosphoryl groups from other molecules during digestion. It can be further classified as a phosphomonoesterase.
Acid phosphatase is stored in lysosomes and functions when these fuse with endosomes, which are acidified while they function; therefore, it has an acid pH optimum. This enzyme is present in many animal and plant species.


  • Henneberry, M.O.; Engel, G.; Grayhack, J.T. (October 1979). “Acid phosphatase“. The Urologic clinics of North America 6 (3): 629–41. PMID 388794.
  • Bull, H.; Murray, P.G.; Thomas, D.; Fraser, A.M.; Nelson, P.N. (April 2002). “Acid phosphatases“. Molecular Pathology 55 (2): 65–72. doi:10.1136/mp.55.2.65. PMC 1187150. PMID 11950951.

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