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Biomarker: Apolipoprotein B

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Analyte:

Apolipoprotein B

Platform:

Disease State:

Status:

Experienced Running

Required Sample Volume:

100 µL/well

Sensitivity-LLOQ/ULOQ:

LLOQ: 6.25 ng/mL
ULOQ: 500 ng/mL

Biological or Clinical Significance:

Apolipoprotein B (ApoB) is a protein that in humans is encoded by the APOB gene. Apolipoprotein B is the primary apolipoprotein of chylomicrons, VLDL, IDL, and LDL particles (LDL – known commonly by the misnomer “bad cholesterol” when in reference to both heart disease and vascular disease in general), which is responsible for carrying fat molecules (lipids), including cholesterol, around the body (within the water outside cells) to all cells within all tissues. While all the functional roles of ApoB within the LDL (and all larger) particles remains somewhat unclear, it is the primary organizing protein (of the entire complex shell enclosing/carrying fat molecules within) component of the particles and is absolutely required for the formation of these particles.

References:

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