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Biomarker: c-Jun (pS63)

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c-Jun (pS63)

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Experienced Running

Biological or Clinical Significance:

The human protooncogene JUN is the putative transforming gene of avian sarcoma virus 17, and it encodes a protein which is highly homologous to the viral protein cJun and c Fos form a complex in the nucleus. AP 1 (activating protein 1) is a collective term referring to these dimeric transcription factors composed of Jun, Fos or ATF subunits that bind to a common DNA site, the AP1 binding site. AP 1 proteins, mostly the Jun group, regulate the expression and function of cell cycle regulators such as Cyclin D1, p53, p21 (cip1/waf1), p19 (ARF) and p16. Fos and Jun proto oncogene expression is induced transiently by a variety of extracellular stimuli associated with mitogenesis, differentiation processes or depolarization of neurons. JUN has been mapped to 1p32 to p31, a chromosomal region involved in both translocations and deletions in human malignancies.

The c-Jun pS63 has been validated in the following applications: IF, IHC Paraffin, WB

References:

  • C-Jun PS63.” Antibody Datasheet. One World Lab, Inc., n.d. Web. 05 Apr. 2016.

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