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Biomarker: Clusterin

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Clusterin

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Experienced Running

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Clusterin (apolipoprotein J) is a 75 – 80 kDa disulfide-linked heterodimeric protein associated with the clearance of cellular debris and apoptosis. In humans, clusterin is encoded by the CLU gene on chromosome 8. CLU is a molecular chaperone responsible for aiding protein folding of secreted proteins, and its three isoforms have been differentially implicated in pro- or antiapoptotic processes. Through this function, CLU is involved in many diseases related to oxidative stress, including neurodegenerative diseases, cancers, inflammatory diseases, and aging.

Two independent genome-wide association studies found a statistical association between a SNP within the clusterin gene and the risk of having Alzheimer’s disease. Further studies have suggested that people who already have Alzheimer’s disease have more clusterin in their blood, and that clusterin levels in blood correlate with faster cognitive decline in individuals with Alzheimer’s disease, but have not found that clusterin levels predicted the onset of Alzheimer’s disease. In addition to Alzheimer’s disease, CLU is involved in other neurodegenerative diseases such as Huntington disease.

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