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Biomarker: DJ-1 (PARK7)

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DJ-1 (PARK7)



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Biological or Clinical Significance:

Protein deglycase DJ-1, also known as Parkinson disease protein 7, is a protein which in humans is encoded by the PARK7 gene. The gene PARK7, also known as DJ-1, encodes a protein of the peptidase C56 family. The human gene PARK7 has 8 Exons and locates at chromosome band 1p36.23. The human protein deglycase DJ-1 is 20 kDa in size and composed of 189 amino acids with seven β-strands and nine α-helices in total and is present as a dimer.[3][4][5] It belongs to the peptidase C56 family of proteins. Defects in this gene are the cause of autosomal recessive early-onset Parkinson’s disease 7.


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