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Biomarker:

E-Selectin

Biological or Clinical Significance:

E-selectin, also known as CD62 antigen-like family member E (CD62E), endothelial-leukocyte adhesion molecule 1 (ELAM-1), or leukocyte-endothelial cell adhesion molecule 2 (LECAM2), is a cell adhesion molecule expressed only on endothelial cells activated by cytokines. Like other selectins, it plays an important part in inflammation. In humans, E-selectin is encoded by the SELE gene. E selectin has a cassette structure: an N-terminal, C-type lectin domain, an EGF (epidermal-growth-factor)-like domain, 6 Sushi domain (SCR repeat) units, a transmembrane domain (TM) and an intracellular cytoplasmic tail (cyto). E-selectin is also an emerging biomarker for the metastatic potential of some cancers including colorectal cancer and recurrences.

References:

Analyte:

E-Selectin

Matrix:

Human Plasma

Status:

Experienced Running

Sensitivity-LLOQ:

Sensitivity-ULOQ:

platform

Luminex, MSD-ECL

Required Sample Volume

Disease State:

MSD Panel:

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