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Biomarker:

ENA-78

Biological or Clinical Significance:

C-X-C motif chemokine 5 (CXCL5 or ENA78) is a protein that in humans is encoded by the CXCL5 gene. CXCL5 plays a role in reducing sensitivity to sunburn pain in some subjects, and is a “potential target which can be utilized to understand more about pain in other inflammatory conditions like arthritis and cystitis.” CXCL5 is well known to have chemotactic and activating functions on neutrophil, mainly during acute inflammatory responses. However CXCL5 expression is also higher in atherosclerosis (a chronic inflammatory condition) but is not associated with neutrophil infiltration. Instead CXCL5 has a protective role in atherosclerosis by directly controlling macrophage foam cell formation.

References:

Sepuru, K. M.; Poluri, K. M.; Rajarathnam, K. (2014). “Solution Structure of CXCL5 — A Novel Chemokine and Adipokine Implicated in Inflammation and Obesity”. PLoS ONE 9 (4): e93228. doi:10.1371/journal.pone.0093228. PMC 3973705. PMID 24695525.

Chang MS, McNinch J, Basu R, Simonet S (Nov 1994). “Cloning and characterization of the human neutrophil-activating peptide (ENA-78) gene”. J Biol Chem 269 (41): 25277–82. PMID 7929219.

Analyte:

ENA-78

Matrix:

Status:

Experienced Running

Sensitivity-LLOQ:

Sensitivity-ULOQ:

platform

MSD-ECL

Required Sample Volume

Disease State:

MSD Panel:

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