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Biomarker:

GDF-15 (serum)

Biological or Clinical Significance:

Growth differentiation factor 15 (GDF15) is a protein belonging to the transforming growth factor beta superfamily that has a role in regulating inflammatory and apoptotic pathways in injured tissues and during disease processes. GDF15 is also known as TGF-PL, MIC-1, PDF, PLAB, and PTGFB. GDF15 mRNA is most abundant in the liver, with lower levels seen in some other tissues. Its expression in liver can be significantly up-regulated in during injury of organs such as liver, kidney, heart and lung.

References:

Analyte:

GDF-15 (serum)

Matrix:

Human Serum

Status:

Validated

Sensitivity-LLOQ:

25 pg/mL

Sensitivity-ULOQ:

2,800 pg/mL

platform

ELISA

Required Sample Volume

50 µL/well

Disease State:

Oncology

MSD Panel:

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