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Biomarker: GDF-15 (serum)

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Analyte:

GDF-15 (serum)

Platform:

Matrix:

Human Serum

Disease State:

Status:

Validated

Required Sample Volume:

50 µL/well

Sensitivity-LLOQ/ULOQ:

LLOQ: 25 pg/mL
ULOQ: 2,800 pg/mL

Biological or Clinical Significance:

Growth differentiation factor 15 (GDF15) is a protein belonging to the transforming growth factor beta superfamily that has a role in regulating inflammatory and apoptotic pathways in injured tissues and during disease processes. GDF15 is also known as TGF-PL, MIC-1, PDF, PLAB, and PTGFB. GDF15 mRNA is most abundant in the liver, with lower levels seen in some other tissues. Its expression in liver can be significantly up-regulated in during injury of organs such as liver, kidney, heart and lung.

References:

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