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Biomarker:

GM-CSF

Biological or Clinical Significance:

Granulocyte-macrophage colony-stimulating factor (GM-CSF), also known as colony stimulating factor 2 (CSF2), is a monomeric glycoprotein secreted by macrophages, T cells, mast cells, NK cells, endothelial cells and fibroblasts that functions as a cytokine. The pharmaceutical analogs of naturally occurring GM-CSF are called sargramostim and molgramostim. GM-CSF is a monomeric glycoprotein that functions as a cytokine – it is a white blood cell growth factor. GM-CSF stimulates stem cells to produce granulocytes (neutrophils, eosinophils, and basophils) and monocytes. GM-CSF signals via signal transducer and activator of transcription, STAT5. In macrophages, it has also been shown to signal via STAT3. GM-CSF also plays a role in embryonic development by functioning as an embryokine produced by reproductive tract.

References:

Analyte:

GM-CSF

Matrix:

Human K2 EDTA Plasma

Status:

Validated

Sensitivity-LLOQ:

1.734 pg/mL

Sensitivity-ULOQ:

968 pg/mL

platform

MSD-ECL

Required Sample Volume

50 µL/well

Disease State:

Autoimmune

MSD Panel:

Cytokine Panel 1 (Human)

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