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Biomarker: GM-CSF

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Analyte:

GM-CSF

Platform:

Matrix:

Human K2 EDTA Plasma

Disease State:

Status:

Validated

Required Sample Volume:

50 µL/well

Sensitivity-LLOQ/ULOQ:

LLOQ: 1.734 pg/mL
ULOQ: 968 pg/mL

Biological or Clinical Significance:

Granulocyte-macrophage colony-stimulating factor (GM-CSF), also known as colony stimulating factor 2 (CSF2), is a monomeric glycoprotein secreted by macrophages, T cells, mast cells, NK cells, endothelial cells and fibroblasts that functions as a cytokine. The pharmaceutical analogs of naturally occurring GM-CSF are called sargramostim and molgramostim. GM-CSF is a monomeric glycoprotein that functions as a cytokine – it is a white blood cell growth factor. GM-CSF stimulates stem cells to produce granulocytes (neutrophils, eosinophils, and basophils) and monocytes. GM-CSF signals via signal transducer and activator of transcription, STAT5. In macrophages, it has also been shown to signal via STAT3. GM-CSF also plays a role in embryonic development by functioning as an embryokine produced by reproductive tract.

References:

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