Biomarker Menu
Biomarker Menu

Explore Our Biomarker Menu

Including 400+ Biomarker Offerings for a Range of Disease States

Return to Biomarker Menu

Biomarker: GSK-3α (pS21)

Search for Biomarkers


GSK-3α (pS21)



Experienced Running

Biological or Clinical Significance:

Glycogen synthase kinase 3, a serine/threonine kinase involved in multiple physiological processes is a highly conserved and ubiquitously expressed member of the CMGC family of protein kinases. To date, two members of the mammalian GSK3 family (α and β) are known. GSK3α/β plays a major role in epithelial cell homeostasis. GSK3 proteins usually have three domains, a small N-terminal domain, a slightly larger C-terminal domain and a predominant middle kinase domain. In addition to these domains, a nuclear localization sequence has also recently been identified. Its paradoxical role as a tumor suppressor or a tumor promoter is actively under investigation in various neoplastic diseases. GSK3 is a constitutively active enzyme in normal cells and undergoes rapid inhibition by stimuli. The activity of GSK3 is inhibited upon phosphorylation at Ser21 of GSK3α and at Ser9 of GSK3β. GSK3 is a key suppressor of the canonical Wnt signaling pathway including β-catenin and various other oncogenic transcription factors (OTFs), such as NFκB, AP-1, c-Myc and p53, which are involved in cell proliferation.


Speak to a Scientist

    What would you like to discuss?

    With whom will we be speaking?

    I consent to receive communications (which may include, phone, email, social, and re-targeting ads) from BioAgilytix. I understand I may proactively manage my preferences or opt-out of communications with BioAgilytix at any time using the unsubscribe link provided in all of BioAgilytix’s email communications and can learn more by reading the privacy policy.

    Yes I confirm that I am over the age of 16 and I consent to communications from BioAgilytix.

    biomarker services


    See how our premier bioanalytical services support all phases of biomarker, immunogenicity, PK, and cell-based assay studies.

    Explore our services

    case studies

    Case Studies

    Learn why we’re a trusted partner to 22 of the top 25 global pharma and biotech companies.

    Read our case studies