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Biomarker:

IFN-β (serum)

Biological or Clinical Significance:

Interferon consensus sequence-binding protein (ICSBP) is a transcription factor of the interferon (IFN) regulatory factor (IRF) family. Proteins of this family are composed of a conserved DNA-binding domain in the N-terminal region and a divergent C-terminal region that serves as the regulatory domain. The IRF family proteins bind to the IFN-stimulated response element (ISRE) and regulate expression of genes stimulated by type I IFNs, namely IFN-alpha and IFN-beta. IRF family proteins also control expression of IFN-alpha and IFN-beta-regulated genes that are induced by viral infection.

References:

  • IRF8.” (n.d.): n. pag. The Human Protein Atlas. Web.  

Analyte:

IFN-β (serum)

Matrix:

Human Serum

Status:

Experienced Running

Sensitivity-LLOQ:

6.16 pg/mL

Sensitivity-ULOQ:

platform

Ella

Required Sample Volume

Disease State:

MSD Panel:

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