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Biomarker:

IGF-1R (total)

Biological or Clinical Significance:

The insulin-like growth factor 1 (IGF-1) receptor is a protein found on the surface of human cells. It is a transmembrane receptor that is activated by a hormone called insulin-like growth factor 1 (IGF-1) and by a related hormone called IGF-2. IGF-1 plays an important role in growth and continues to have anabolic effects in adults – meaning that it can induce hypertrophy of skeletal muscle and other target tissues. Mice lacking the IGF-1 receptor die late in development, and show a dramatic reduction in body mass, testifying to the strong growth-promoting effect of this receptor. Mice carrying only one functional copy of IGF-1R are normal, but exhibit a ~15% decrease in body mass.

References:

Analyte:

IGF-1R (total)

Matrix:

null

Status:

Validated

Sensitivity-LLOQ:

Sensitivity-ULOQ:

platform

Luminex, MSD-ECL

Required Sample Volume

null

Disease State:

null

MSD Panel:

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