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Biomarker:

IL-1α

Biological or Clinical Significance:

The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is a pleiotropic cytokine involved in various immune responses, inflammatory processes, and hematopoiesis. This cytokine is produced by monocytes and macrophages as a proprotein, which is proteolytically processed and released in response to cell injury, and thus induces apoptosis. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. It has been suggested that the polymorphism of these genes is associated with rheumatoid arthritis and Alzheimer’s disease.

References:

  • IL1A.” (n.d.): n. pag. The Human Protein Atlas. Web.  

Analyte:

IL-1α

Matrix:

Human Plasma

Status:

Validated

Sensitivity-LLOQ:

1.62 pg/mL

Sensitivity-ULOQ:

366 pg/mL

platform

MSD-ECL

Required Sample Volume

50 µL/well

Disease State:

MSD Panel:

Cytokine Panel 1 (Human)

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