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Biomarker:

IL-10 (plasma, serum)

Biological or Clinical Significance:

Interleukin 10 (IL-10), also known as human cytokine synthesis inhibitory factor (CSIF), is an anti-inflammatory cytokine. In humans, interleukin 10 is encoded by the IL10 gene. IL-10 signals through a receptor complex consisting of two IL-10 receptor-1 and two IL-10 receptor 2 proteins. Consequently, the functional receptor consists of four IL-10 receptor molecules. IL-10 binding induces STAT3 signalling via the phosphorylation of the cytoplasmic tails of IL-10 receptor 1 + IL-10 receptor 2 by JAK1 and Tyk2 respectively.

IL-10 is a cytokine with multiple, pleiotropic, effects in immunoregulation and inflammation. It downregulates the expression of Th1 cytokines, MHC class II antigens, and co-stimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. IL-10 can block NF-κB activity, and is involved in the regulation of the JAK-STAT signaling pathway.

References:

Analyte:

IL-10 (plasma, serum)

Matrix:

Human Serum and K2 EDTA Plasma

Status:

Experienced Running

Sensitivity-LLOQ:

10.8 pg/mL

Sensitivity-ULOQ:

7,900 pg/mL

platform

Luminex

Required Sample Volume

100 µL/well

Disease State:

Autoimmune

MSD Panel:

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