Interleukin-12 p70 (IL-12p70) heterodimer, composed of p35 and p40 subunits, is a major Th1-driving cytokine, promoting cell-mediated immunity. Inability of TNFa/PGE2 to induce IL-12p70 strongly enhances the lipopolysaccharide (LPS)–induced IL-12p70 production. In addition to the selective induction of IL-12p40 in TNFa-stimulated DCs, PGE2 inhibits the production of IL-12p70 in DCs stimulated with LPS or CD40 ligand. Suppression of bioactive IL-12p70 may have negative impact on anticancer
vaccination with PGE2-matured DCs.
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