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Biomarker: IL-13 (plasma)

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Analyte:

IL-13 (plasma)

Platform:

Matrix:

Human K2 EDTA Plasma

Status:

Validated

Required Sample Volume:

50 µL/well

Sensitivity-LLOQ/ULOQ:

LLOQ: 0.976 pg/mL
ULOQ: 9.76 pg/mL

Biological or Clinical Significance:

Interleukin 13 (IL-13) is a protein that in humans is encoded by the IL13 gene. IL-13 is located on chromosome 5q31 with a length of 1.4kb. IL-13 and IL-4 exhibit a 30% of sequence similarity and have a similar structure. IL-13 is cytokine secreted by many cell types, but especially T helper type 2 (Th2) cells, which is a mediator of allergic inflammation and disease.

IL-13 specifically induces physiological changes in parasitized organs that are required to expel the offending organisms or their products. For example, expulsion from the gut of a variety of mouse helminths requires IL-13 secreted by Th2 cells. IL-13 induces several changes in the gut that create an environment hostile to the parasite, including enhanced contractions and glycoprotein hyper-secretion from gut epithelial cells, that ultimately lead to detachment of the organism from the gut wall and their removal.

References:

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