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Biomarker:

IL-13 (serum)

Biological or Clinical Significance:

Interleukin 13 (IL-13) is a protein that in humans is encoded by the IL13 gene. IL-13 is located on chromosome 5q31 with a length of 1.4kb. IL-13 and IL-4 exhibit a 30% of sequence similarity and have a similar structure. IL-13 is cytokine secreted by many cell types, but especially T helper type 2 (Th2) cells, which is a mediator of allergic inflammation and disease.

IL-13 specifically induces physiological changes in parasitized organs that are required to expel the offending organisms or their products. For example, expulsion from the gut of a variety of mouse helminths requires IL-13 secreted by Th2 cells. IL-13 induces several changes in the gut that create an environment hostile to the parasite, including enhanced contractions and glycoprotein hyper-secretion from gut epithelial cells, that ultimately lead to detachment of the organism from the gut wall and their removal.

References:

Analyte:

IL-13 (serum)

Matrix:

Human Serum

Status:

Validated

Sensitivity-LLOQ:

0.442 pg/mL

Sensitivity-ULOQ:

382 pg/mL

platform

MSD-ECL

Required Sample Volume

50 µL/well

Disease State:

MSD Panel:

Proinflammatory Panel 1 (Human)

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