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Biomarker:

IL-18 (plasma)

Biological or Clinical Significance:

Interleukin-18 (IL18, also known as interferon-gamma inducing factor) is a protein which in humans is encoded by the IL18 gene. The protein encoded by this gene is a proinflammatory cytokine. Apart from its physiological role, IL-18 is also able to induce severe inflammatory reactions, which suggests its role in certain inflammatory disorders. Endometrial IL-18 receptor mRNA and the ratio of IL-18 binding protein to interleukin 18 are significantly increased in adenomyosis patients in comparison to normal people, indicating a role in its pathogenesis. IL-18 has been implicated as an inflammatory mediator of Hashimoto’s thyroiditis, the most common cause of autoimmune hypothyroidism. IL-18 is up regulated by interferon-gamma. IL-18 has also been found to increase the Alzheimer’s disease-associated amyloid-beta production in human neuron cells.

References:

Analyte:

IL-18 (plasma)

Matrix:

Human K2 EDTA Plasma

Status:

Experienced Running

Sensitivity-LLOQ:

7.03 pg/mL

Sensitivity-ULOQ:

28,800 pg/mL

platform

Luminex, MSD-ECL

Required Sample Volume

50 µL/well

Disease State:

MSD Panel:

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