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Biomarker:

IL-1β (mouse)

Biological or Clinical Significance:

Interleukin 1 beta (IL1β) is a cytokine protein that in humans is encoded by the IL1B gene. IL-1β precursor is cleaved by cytosolic caspase 1 (interleukin 1 beta convertase) to form mature IL-1β. Increased production of IL-1B causes a number of different autoinflammatory syndromes, most notably the monogenic conditions referred to as CAPS, due to mutations in the inflammasome receptor NLRP3 which triggers processing of IL-1B.

References:

Analyte:

IL-1β (mouse)

Matrix:

Mouse Serum

Status:

Experienced Running

Sensitivity-LLOQ:

1.98 pg/mL

Sensitivity-ULOQ:

7,200 pg/mL

platform

MSD-ECL

Required Sample Volume

25 µL/well

Disease State:

Autoimmune

MSD Panel:

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