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Biomarker: IL-27

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Analyte:

IL-27

Platform:

Matrix:

Human K2 EDTA Plasma

Status:

Experienced Running

Required Sample Volume:

50 µL/well

Sensitivity-LLOQ/ULOQ:

LLOQ: 39.9 pg/mL
ULOQ: 163,700 pg/mL

Biological or Clinical Significance:

Interleukin 27 (IL27) is a heterodimeric cytokine belonging to the IL-12 family that is composed of two subunits; Epstein-Barr virus (EBV)-induced gene 3 (EBI3) (also known as IL-27B) and IL27-p28 (known as IL-30). IL-27 is produced by antigen-presenting cells.

IL-27 plays an important function in regulating the activity of B- and T-lymphocytes. The effects of IL-27 are eliciting by its interaction with a specific cell-surface receptor complex composed of two proteins known as IL27R and gp130.

References:

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