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Biomarker:

IL-4 (plasma)

Biological or Clinical Significance:

The interleukin 4 (IL-4) is a cytokine that induces differentiation of naive helper T cells (Th0 cells) to Th2 cells. Upon activation by IL-4, Th2 cells subsequently produce additional IL-4 in a positive feedback loop. The cell that initially produces IL-4, thus inducing Th0 differentiation, has not been identified, but recent studies suggest that basophils may be the effector cell. It is closely related and has functions similar to Interleukin 13.

IL-4 also has been shown to drive mitogenesis, dedifferentiation, and metastasis in rhabdomyosarcoma. IL-4, along with other Th2 cytokines, is involved in the airway inflammation observed in the lungs of patients with allergic asthma.

References:

Analyte:

IL-4 (plasma)

Matrix:

Human K2 EDTA Plasma

Status:

Validated

Sensitivity-LLOQ:

0.760 pg/mL

Sensitivity-ULOQ:

159.2 pg/mL

platform

MSD-ECL

Required Sample Volume

50 µL/well

Disease State:

Autoimmune

MSD Panel:

Proinflammatory Panel 1 (Human)

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