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Biomarker: IL-7 (serum)

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Analyte:

IL-7 (serum)

Platform:

Matrix:

Human Serum

Disease State:

Status:

Experienced Running

Required Sample Volume:

50 µL/well

Biological or Clinical Significance:

IL-7 is a hematopoietic growth factor secreted by stromal cells in the bone marrow and thymus. It is also produced by keratinocytes, dendritic cells, hepatocytes, neurons, and epithelial cells but is not produced by normal lymphocytes.

The three-dimensional structure of IL-7 in complex with the ectodomain of IL7R has been determined using X-ray diffraction. IL-7 stimulates the differentiation of multipotent (pluripotent) hematopoietic stem cells into lymphoid progenitor cells. It also stimulates proliferation of all cells in the lymphoid lineage. IL-7 is a cytokine important for B and T cell development. IL-7 binds to the IL-7 receptor, a heterodimer consisting of Interleukin-7 receptor alpha and common gamma chain receptor.

References:

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