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Biomarker:

IL-7 (plasma)

Biological or Clinical Significance:

IL-7 is a hematopoietic growth factor secreted by stromal cells in the bone marrow and thymus. It is also produced by keratinocytes, dendritic cells, hepatocytes, neurons, and epithelial cells but is not produced by normal lymphocytes.

The three-dimensional structure of IL-7 in complex with the ectodomain of IL7R has been determined using X-ray diffraction. IL-7 stimulates the differentiation of multipotent (pluripotent) hematopoietic stem cells into lymphoid progenitor cells. It also stimulates proliferation of all cells in the lymphoid lineage. IL-7 is a cytokine important for B and T cell development. IL-7 binds to the IL-7 receptor, a heterodimer consisting of Interleukin-7 receptor alpha and common gamma chain receptor.

References:

Analyte:

IL-7 (plasma)

Matrix:

Human K2 EDTA Plasma

Status:

Validated

Sensitivity-LLOQ:

0.480 pg/mL

Sensitivity-ULOQ:

704 pg/mL

platform

MSD-ECL

Required Sample Volume

50 µL/well

Disease State:

Autoimmune

MSD Panel:

Cytokine Panel 1 (Human)

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