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Biomarker:

IL-8 (serum)

Biological or Clinical Significance:

Interleukin 8 (IL8 or chemokine (C-X-C motif) ligand 9, CXCL8) is a chemokine produced by macrophages and other cell types such as epithelial cells, airway smooth muscle cells and endothelial cells. In humans, the interleukin-8 protein is encoded by the IL8 gene. IL-8 is initially produced as a precursor peptide of 99 amino acids long which then undergoes cleavage to create several active IL-8 isoforms.

Interleukin-8 is a key mediator associated with inflammation where it plays a key role in neutrophil recruitment and neutrophil degranulation. As an example, it has been cited as a proinflammatory mediator in gingivitis and psoriasis. IL-8 has also been implied to have a role in colorectal cancer by acting as an autocrine growth factor for colon carcinoma cell lines or the promotion of division and possible migration by cleaving metalloproteinase molecules.

References:

Analyte:

IL-8 (serum)

Matrix:

Human Serum

Status:

Validated

Sensitivity-LLOQ:

0.218 pg/mL

Sensitivity-ULOQ:

378 pg/mL

platform

MSD-ECL

Required Sample Volume

50 µL/well

Disease State:

Autoimmune

MSD Panel:

Chemokine Panel 1 (Human)

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