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Biomarker: IL-8 (serum)

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Analyte:

IL-8 (serum)

Platform:

Matrix:

Human Serum

Disease State:

Status:

Validated

Required Sample Volume:

50 µL/well

Sensitivity-LLOQ/ULOQ:

LLOQ: 0.218 pg/mL
ULOQ: 378 pg/mL

Biological or Clinical Significance:

Interleukin 8 (IL8 or chemokine (C-X-C motif) ligand 9, CXCL8) is a chemokine produced by macrophages and other cell types such as epithelial cells, airway smooth muscle cells and endothelial cells. In humans, the interleukin-8 protein is encoded by the IL8 gene. IL-8 is initially produced as a precursor peptide of 99 amino acids long which then undergoes cleavage to create several active IL-8 isoforms.

Interleukin-8 is a key mediator associated with inflammation where it plays a key role in neutrophil recruitment and neutrophil degranulation. As an example, it has been cited as a proinflammatory mediator in gingivitis and psoriasis. IL-8 has also been implied to have a role in colorectal cancer by acting as an autocrine growth factor for colon carcinoma cell lines or the promotion of division and possible migration by cleaving metalloproteinase molecules.

References:

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