Explore Our Biomarker Menu


Immunoglobulin Isotyping

Biological or Clinical Significance:

Immunoglobulin isotype refers to the slight phenotypic variations within the immunoglobulin gene family that encode for variant immunoglobulin heavy chains and immunoglobulin light chains. In humans, there are five heavy chain isotypes and two light chain isotypes, which differ in function and antigen responses primarily due to structure variability:

Heavy Chain
• IgA
• IgD
• IgG
• IgE
• IgM

Light Chain
• κ
• λ

The Immunoglobulins IgG and IgA are further grouped into subclasses (e.g. in Human IgG1, IgG2, IgG3, IgG4, IgA1 and IgA2) based on additional small differences in the amino acid heavy chain sequences.



Immunoglobulin Isotyping



Experienced Running





Required Sample Volume

Disease State:

MSD Panel:

Speak To A Scientist

    I consent to receive communications (which may include, phone, email, social, and re-targeting ads) from BioAgilytix. I understand I may proactively manage my preferences or opt-out of communications with BioAgilytix at any time using the unsubscribe link provided in all of BioAgilytix’s email communications and can learn more by reading the privacy policy.


    Learn why BioAgilytix is a world-leading authority on immunogenicity studies related to ADA, NAb assay development and validation, isotyping, and more.

    Case Studies

    Learn why we’re a trusted partner to 22 of the top 25 global pharma and biotech companies.