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Biomarker: MMP-9

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Analyte:

MMP-9

Platform:

Matrix:

Plasma

Status:

Experienced Running

Biological or Clinical Significance:

Matrix metallopeptidase 9 (MMP-9) is a matrixin, a class of enzymes that belong to the zinc-metalloproteinases family involved in the degradation of the extracellular matrix. In humans the MMP9 gene encodes for a signal peptide, a propeptide, a catalytic domain with inserted three repeats of fibronectin type II domain followed by a C-terminal hemopexin-like domain.

MMP9 has been found to be associated with numerous pathological processes, including cancer, immunologic and cardiovascular diseases. One of MMP9’s most widely-associated pathologies is the relationship to cancer, due to its role in extracellular matrix remodeling and angiogenesis. For example, its increased expression was seen in a metastatic mammary cancer cell line. In addition, MMP9 levels increase with the progression of idiopathic atrial fibrillation.

References:

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