The Cleaved-PARP-1 (D214) pAb Antibody is a Rabbit Polyclonal antibody to PARP, PPOL, ADPRT, ADPRT1, PARP-1, PARP1, poly (ADP-ribose) polymerase 1, ARTD1. This antibody recognizes Rat, Mouse, Human antigen. The Cleaved-PARP-1 (D214) pAb Antibody has been validated for the following applications: Western Blot.

PARP, a 116 kDa nuclear poly (ADP-ribose) polymerase, appears to be involved in DNA repair in response to environmental stress. This protein can be cleaved by many ICE-like caspases in vitro and is one of the main cleavage targets of caspase-3 in vivo (4,5). In human PARP, the cleavage occurs between Asp214 and Gly215, which separates the PARP amino-terminal DNA binding domain (24 kDa) from the carboxy-terminal catalytic domain (89 kDa) (2,4). PARP helps cells to maintain their viability; cleavage of PARP facilitates cellular disassembly and serves as a marker of cells undergoing apoptosis (6).