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Biomarker: RON (pT1238/1239)

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RON (pT1238/1239)



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Biological or Clinical Significance:

Ron, also designated STK in mice, is a transmembrane receptor tyrosine kinase that is a member of the Met family and displays 63% homology with Met. The gene encoding human Ron maps to chromosome 3p21 and is expressed as a glycosylated precursor, which is cleaved to produce a heterodimer of alpha and beta disulfide-linked chains. Ron is expressed in several epithelial tissues, granulocytes and monocytes, and it is the membrane bound receptor for macrophage-stimulating protein (MSP), a multifunctional factor that regulates cell adhesion, motility, growth and survival. Binding of MSP to Ron stimulates tyrosine phosphorylation on Tyr 1238 and Tyr 1239. This phosphorylation leads to a upregulation of Ron catalytic activity and subsequent activation of downstream signaling molecules. In addition, Ron contains putative autophosphorylation sites on Tyr 1353 and Tyr 1360. Ron is thought to play a role in early embryonic development and in the inflammatory response.

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