Biomarker Menu
Biomarker Menu

Explore Our Biomarker Menu

Including 400+ Biomarker Offerings for a Range of Disease States

Return to Biomarker Menu

Biomarker: RON (pT1238/1239)

Search for Biomarkers

Analyte:

RON (pT1238/1239)

Platform:

Status:

Experienced Running

Biological or Clinical Significance:

Ron, also designated STK in mice, is a transmembrane receptor tyrosine kinase that is a member of the Met family and displays 63% homology with Met. The gene encoding human Ron maps to chromosome 3p21 and is expressed as a glycosylated precursor, which is cleaved to produce a heterodimer of alpha and beta disulfide-linked chains. Ron is expressed in several epithelial tissues, granulocytes and monocytes, and it is the membrane bound receptor for macrophage-stimulating protein (MSP), a multifunctional factor that regulates cell adhesion, motility, growth and survival. Binding of MSP to Ron stimulates tyrosine phosphorylation on Tyr 1238 and Tyr 1239. This phosphorylation leads to a upregulation of Ron catalytic activity and subsequent activation of downstream signaling molecules. In addition, Ron contains putative autophosphorylation sites on Tyr 1353 and Tyr 1360. Ron is thought to play a role in early embryonic development and in the inflammatory response.

Speak to a Scientist

















What would you like to discuss?

With whom will we be speaking?






I consent to receive communications (which may include, phone, email, social, and re-targeting ads) from BioAgilytix. I understand I may proactively manage my preferences or opt-out of communications with BioAgilytix at any time using the unsubscribe link provided in all of BioAgilytix’s email communications and can learn more by reading the privacy policy.

Yes I confirm that I am over the age of 16 and I consent to communications from BioAgilytix.


biomarker services

Services

See how our premier bioanalytical services support all phases of biomarker, immunogenicity, PK, and cell-based assay studies.

Explore our services

case studies

Case Studies

Learn why we’re a trusted partner to 22 of the top 25 global pharma and biotech companies.

Read our case studies