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Biomarker: SCF

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Analyte:

SCF

Platform:

Matrix:

Human K2 EDTA Plasma

Status:

Experienced Running

Sensitivity-LLOQ/ULOQ:

LLOQ: 1.68 pg/mL
ULOQ: 6,900 pg/mL

Biological or Clinical Significance:

Stem cell factor is a cytokine that binds to the c-KIT receptor (CD117). SCF can exist both as a transmembrane protein and a soluble protein. This cytokine plays an important role in hematopoiesis, spermatogenesis, and melanogenesis.

SCF may be used along with other cytokines to culture HSCs and hematopoietic progenitors. The expansion of these cells ex-vivo would allow advances in bone marrow transplantation, in which HSCs are transferred to a patient to re-establish blood formation. One of the problems of injecting SCF for therapeutic purposes is that SCF activates mast cells. The injection of SCF has been shown to cause allergic-like symptoms and the proliferation of mast cells and melanocytes.

References:

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