Biomarker Menu
Biomarker Menu

Explore Our Biomarker Menu

Including 400+ Biomarker Offerings for a Range of Disease States

Return to Biomarker Menu

Biomarker: SDF-1α

Search for Biomarkers

Analyte:

SDF-1α

Platform:

Matrix:

Human K2 EDTA plasma

Disease State:

null

Status:

Offered

Required Sample Volume:

null

Sensitivity-LLOQ/ULOQ:

LLOQ: 9.52 pg/mL
ULOQ: 39,000 pg/mL

Biological or Clinical Significance:

Stromal cell-derived factors 1-alpha and 1-beta, also known as (CXCL12), are small cytokines that belong to the chemokine family, encoded by the CXCL12 gene. The chemokines are characterized by the presence of 4 conserved cysteines that form 2 disulfide bonds. CXCL12 is strongly chemotactic for lymphocytes. During embryogenesis it directs the migration of hematopoietic cells from foetal liver to bone marrow and the formation of large blood vessels. CXCL12 also has a role in tumor metastasis where cancer cells that express the receptor CXCR4 are attracted to metastasis target tissues that release the ligand, CXCL12. CXCL12 is expressed in the area of inflammatory bone destruction. It is chemotactic for mesenchymal stem cells and mediates their suppressive effect on osteoclastogenesis.

References:

Speak to a Scientist

















What would you like to discuss?

With whom will we be speaking?






I consent to receive communications (which may include, phone, email, social, and re-targeting ads) from BioAgilytix. I understand I may proactively manage my preferences or opt-out of communications with BioAgilytix at any time using the unsubscribe link provided in all of BioAgilytix’s email communications and can learn more by reading the privacy policy.

Yes I confirm that I am over the age of 16 and I consent to communications from BioAgilytix.


biomarker services

Services

See how our premier bioanalytical services support all phases of biomarker, immunogenicity, PK, and cell-based assay studies.

Explore our services

case studies

Case Studies

Learn why we’re a trusted partner to 22 of the top 25 global pharma and biotech companies.

Read our case studies