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Biomarker:

sIL-6R

Biological or Clinical Significance:

This gene encodes a subunit of the interleukin 6 (IL6) receptor complex. Interleukin 6 is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in the immune response. The IL6 receptor is a protein complex consisting of this protein and interleukin 6 signal transducer (IL6ST/GP130/IL6-beta), a receptor subunit also shared by many other cytokines. Dysregulated production of IL6 and this receptor are implicated in the pathogenesis of many diseases, such as multiple myeloma, autoimmune diseases and prostate cancer. Alternatively spliced transcript variants encoding distinct isoforms have been reported. A pseudogene of this gene is found on chromosome 9.

References:

  • IL6R.” (n.d.): n. pag. The Human Protein Atlas. Web.  

Analyte:

sIL-6R

Matrix:

Human Serum

Status:

Experienced Running

Sensitivity-LLOQ:

61.1 pg/mL

Sensitivity-ULOQ:

250,000 pg/mL

platform

Luminex

Required Sample Volume

50 µL/well

Disease State:

Oncology

MSD Panel:

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