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Biological or Clinical Significance:

Met is a receptor tyrosine kinase often expressed in epithelium. Its paracrine ligand, hepatocyte growth factor (“scatter factor”), is produced by stromal cells. Met signals via Ras, pi3k/Akt, and stat, affecting mitosis, survival, angiogenesis, migration, invasion, and as implied, mesenchymal–epithelial transversion. Upregulation in cancer cells results in “invasive growth.” Amplification of MET is documented in 4.1% of North American lung adenocarcinomas, but MET overexpression maybe more commonc. Mutations in MET occur rarely.

References:

Analyte:

sMet

Matrix:

null

Status:

Offered

Sensitivity-LLOQ:

Sensitivity-ULOQ:

platform

MSD-ECL

Required Sample Volume

null

Disease State:

null

MSD Panel:

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