Biomarker Menu
Biomarker Menu

Explore Our Biomarker Menu

Including 400+ Biomarker Offerings for a Range of Disease States

Return to Biomarker Menu

Biomarker: sTN1 (Muscle panel)

Search for Biomarkers


sTN1 (Muscle panel)



Rat Serum


Experienced Running

Required Sample Volume:

25 µL/well


LLOQ: 0.144 ng/mL
ULOQ: 209 ng/mL

Biological or Clinical Significance:

Ctc1/Stn1/Ten1 complex is important for telomere maintenance.The essential role of hStn1 is in promoting efficient replication of lagging-strand telomeric DNA. Human Stn1 protects telomere integrity by promoting efficient lagging-strand synthesis at telomeres and mediating C-strand fill-in. Depletion of hStn1 induces catastrophic telomere shortening, DNA damage response, and early senescence in human somatic cells.
hStn1 deficiency leads to persistent and elevated association of DNA polymerase α (polα) to telomeres, suggesting that hStn1 may modulate the DNA synthesis activity of polα rather than controlling the loading of polα to telomeres. Additionally, data suggest that hStn1 is unlikely to be part of the telomere capping complex. The hStn1 assists DNA polymerases to efficiently duplicate lagging-strand telomeres in order to achieve complete synthesis of telomeric DNA, therefore preventing rapid telomere loss.


  • “Human Stn1 Protects Telomere Integrity by Promoting Efficient Lagging-strand Synthesis at Telomeres and Mediating C-strand Fill-in.” Nature Publishing Group, n.d. Web. 04 May 2016.

Speak to a Scientist

    What would you like to discuss?

    With whom will we be speaking?

    I consent to receive communications (which may include, phone, email, social, and re-targeting ads) from BioAgilytix. I understand I may proactively manage my preferences or opt-out of communications with BioAgilytix at any time using the unsubscribe link provided in all of BioAgilytix’s email communications and can learn more by reading the privacy policy.

    Yes I confirm that I am over the age of 16 and I consent to communications from BioAgilytix.

    biomarker services


    See how our premier bioanalytical services support all phases of biomarker, immunogenicity, PK, and cell-based assay studies.

    Explore our services

    case studies

    Case Studies

    Learn why we’re a trusted partner to 22 of the top 25 global pharma and biotech companies.

    Read our case studies