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Biomarker: TARC (CCL17) (serum)

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Analyte:

TARC (CCL17) (serum)

Platform:

Matrix:

Human Serum

Status:

Experienced Running

Required Sample Volume:

50 µL/well

Sensitivity-LLOQ/ULOQ:

LLOQ: 1.04 pg/mL

Biological or Clinical Significance:

This antimicrobial gene is one of several Cys-Cys (CC) cytokine genes clustered on the q arm of chromosome 16. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for T lymphocytes, but not monocytes or granulocytes. The product of this gene binds to chemokine receptors CCR4 and CCR8. This chemokine plays important roles in T cell development in thymus as well as in trafficking and activation of mature T cells.

References:

  • CCL17.” (n.d.): n. pag. The Human Protein Atlas. Web.  

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