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Biomarker:

TNF-β (LTA)

Biological or Clinical Significance:

Lymphotoxin-alpha (LT-alpha) or Tumor necrosis factor-beta (TNF-β) is a protein that in humans is encoded by the LTA gene. Lymphotoxin alpha, a member of the tumor necrosis factor family, is a cytokine produced by lymphocytes. LTA is highly inducible, secreted, and exists as homotrimeric molecule. LTA forms heterotrimers with lymphotoxin-beta, which anchors lymphotoxin-alpha to the cell surface. LTA mediates a large variety of inflammatory, immunostimulatory, and antiviral responses. LTA is also involved in the formation of secondary lymphoid organs during development and plays a role in apoptosis. Lymphotoxin alpha has been shown to interact with LTB.

References:

Analyte:

TNF-β (LTA)

Matrix:

Status:

Experienced Running

Sensitivity-LLOQ:

Sensitivity-ULOQ:

platform

Luminex, MSD-ECL

Required Sample Volume

Disease State:

MSD Panel:

Cytokine Panel 1 (Human)

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