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Biomarker: TREM-1

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Analyte:

TREM-1

Platform:

Matrix:

Human Serum

Status:

Experienced Running

Sensitivity-LLOQ/ULOQ:

LLOQ: 4.19 pg/mL

Biological or Clinical Significance:

This gene encodes a receptor belonging to the Ig superfamily that is expressed on myeloid cells. This protein amplifies neutrophil and monocyte-mediated inflammatory responses triggered by bacterial and fungal infections by stimulating release of pro-inflammatory chemokines and cytokines, as well as increased surface expression of cell activation markers. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. 

References:

  • “TREM1.” (n.d.): n. pag. The Human Protein Atlas. Web.  

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