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Biomarker:

TREM-2

Biological or Clinical Significance:

This gene encodes a membrane protein that forms a receptor signaling complex with the TYRO protein tyrosine kinase binding protein. The encoded protein functions in immune response and may be involved in chronic inflammation by triggering the production of constitutive inflammatory cytokines. Defects in this gene are a cause of polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL). Alternative splicing results in multiple transcript variants encoding different isoforms.

References:

  • TREM2.” (n.d.): n. pag. The Human Protein Atlas. Web.  

Analyte:

TREM-2

Matrix:

Human Serum

Status:

Experienced Running

Sensitivity-LLOQ:

9.96 pg/mL

Sensitivity-ULOQ:

platform

Ella

Required Sample Volume

Disease State:

MSD Panel:

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