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Biological or Clinical Significance:

C-fos-induced growth factor (FIGF) (or vascular endothelial growth factor D, VEGF-D) is a vascular endothelial growth factor that in humans is encoded by the FIGF gene. The protein encoded by this gene is a member of the platelet-derived growth factor/vascular endothelial growth factor (PDGF/VEGF) family and is active in angiogenesis, lymphangiogenesis, and endothelial cell growth. This secreted protein undergoes a complex proteolytic maturation, generating multiple processed forms that bind and activate VEGFR-2 and VEGFR-3 receptors. The structure and function of this protein is similar to those of vascular endothelial growth factor C. VEGF-D has been established to be over-expressed in both tumor tissues and patients’ serum samples in several types of human cancer. In addition, VEGF-D expression has been implicated with increased incidence of regional lymph node metastasis. VEGF-D serum levels are significantly elevated in patients with angiosarcoma.


Stacker SA, Caesar C, Baldwin ME, Thornton GE, Williams RA, Prevo R, Jackson DG, Nishikawa S, Kubo H, Achen MG (Feb 2001). “VEGF-D promotes the metastatic spread of tumor cells via the lymphatics”. Nature Medicine 7 (2): 186–91. doi:10.1038/84635. PMID 11175849.




Human K2 EDTA Plasma




39.4 pg/mL


35,286 pg/mL



Required Sample Volume

50 µL/well

Disease State:


MSD Panel:

Angiogenesis Panel 1 (Human)

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