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Biomarker:

YKL-40

Biological or Clinical Significance:

Chitinases catalyze the hydrolysis of chitin, which is an abundant glycopolymer found in insect exoskeletons and fungal cell walls. The glycoside hydrolase 18 family of chitinases includes eight human family members. This gene encodes a glycoprotein member of the glycosyl hydrolase 18 family. The protein lacks chitinase activity and is secreted by activated macrophages, chondrocytes, neutrophils and synovial cells. The protein is thought to play a role in the process of inflammation and tissue remodeling. 

References:

  • CHI2L1.” (n.d.): n. pag. The Human Protein Atlas. Web.  

Analyte:

YKL-40

Matrix:

Human Serum

Status:

Experienced Running

Sensitivity-LLOQ:

5.10 pg/mL

Sensitivity-ULOQ:

platform

Ella

Required Sample Volume

Disease State:

MSD Panel:

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