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Expert perspectives focused on the latest bioanalytical topic & trends

ADCC and CDC Assay: Validation and Optimization

ADCC Antibody dependent cellular cytotoxicity (ADCC) is a mechanism in host immune defense where antibodies bind to an antigen on the surface of a cell, targeting that cell for killing by an immune effector cell, such as a Natural Killer Cell (NK cell). The effector cell “recognizes” the antibody bound cell by binding to the antibody via the Fc gamma receptor (FcγR) and uses a variety of methods to kill

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