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Expert perspectives focused on the latest bioanalytical topic & trends

Genetic Screening and Big Data’s Influence on Drug Production and Biomarker Identification

The Human Genome Project (HGP) was largely successful in its goal to identify the genetic blueprint of life. The scientific community has begun to translate this genetic information to identify new potential therapeutic targets. Further progress may be possible by continuing to screen patients and identifying subsets from a larger disease population that have increased

Strategies To Overcome Bioanalytical Challenges

Strategies to overcome bioanalytical challenges in Cell & Gene Therapies development With advancements in molecular and cellular engineering techniques, the number of cell and gene therapy (C&GTs) drug development programs has increased significantly in the last 5 years. Following the first gene therapy gaining FDA approval in 2017, the biopharma industry quickly expanded within the

Are We Closer to Using the Word “Cures” More Often?

As we look towards the development of the next generation of drugs and therapies, it starts to beg the question of whether we are creating the next “cure” or the next “treatment.” A cure would require actively restoring the patient to full health with no disease left whereas a treatment shows an improvement in health

ADCC and CDC Assay: Validation and Optimization

ADCC Antibody dependent cellular cytotoxicity (ADCC) is a mechanism in host immune defense where antibodies bind to an antigen on the surface of a cell, targeting that cell for killing by an immune effector cell, such as a Natural Killer Cell (NK cell). The effector cell “recognizes” the antibody bound cell by binding to the

Origins of CRISPR: How it Came to Be

Gene editing isn’t a new concept and has been around for decades. In its infancy, gene editing was time-consuming, inaccurate and costly. That all changed when a revolutionary technique called CRISPR took the science community by storm and has since made the process more affordable, efficient and accurate.  CRISPR (Clustered Regularly Interspaced Short Palindromic Repeat)

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