Scientific Posters
Use of Cold Compounds and High Resolution Mass Spectrometry to Quickly Characterize Drug Uptake in Cryopreserved Human Hepatocytes
Using cold compounds, we wanted to present a compelling set of data to show that hepatocytes and HRAM spectrometry can be used to obtain at…
Validated Multi-site GLP-compliant Analysis of Solithromycin (SOLI) in Monkey Plasma Samples Following Filtration to Remove Potentially Active Anthrax Spores
A highly sensitive method was developed and validated to allow monkey plasma samples, potentially containing Bacillus anthracis (B. anthracis) spores
A Quantitative Method for Determining Hyaluronan Content in Plasma by LC/MS/MS and Plasma HA as a PharmacodynamicMarker for PEGylated-Hyaluronidase PH20 (PEGPH20) in a Phase 1b Trial for Pancreatic Ductal Adenocarcinoma
Hyaluronan (HA) is a non-sulfated linear glycosaminoglycan comprised of repeating disaccharide units of n acetylglucosamineand glucuronic acid.
Evaluation of the MSD Multiplex Electrochemiluminescent Immunoassy for the Determination of Cardiac Toxicity Biomarkers in Rat Serum
Published by BioAgilytixIntroductionICH guidelines require that preclinical safety pharmacology studies to assess the risk of cardiotoxicity be conducted before beginning any clinical development program. Investigation…
Evaluation of Multiplex Electrochemiluminescent Immunoassays for Quantitative Determination of Kidney Injury Biomarkers in Rat Urine
Published by BioAgilytixIntroduction Traditional clinical markers of kidney injury, such as BUN and serum creatinine, lack sufficient sensitivity for early detection of injury and are…