Non-Proprietary Assay List - Bioanalytical Lab & Top CRO for Large Molecule Bioanalysis

Overcoming Bioanalytical Hurdles In The Pharma And Life Sciences Sector

September 27, 2022

Summary Jim McNally’s article, ‘Overcoming bioanalytical hurdles in the pharma and life sciences sector,’ is now available in Manufacturing Chemist magazine: Click

Researcher adding samples to a 96 well plate

Analytical Assays Determine Biosimilar Product Quality

August 6, 2020

Summary In an article published by Pharmaceutical Technology Europe, BioAgilytix BioAgilytix supplies its assay expertise to describe the appropriate analytical

Drug	Species	Matrix	Technique	Anticoagulant	Extraction Volume	Range	Stable Labeled I.S.
2-Deoxy-D-Glucose	Human	Plasma	LC/MS/MS	Heparin	0.1 mL	0.25-50 µg/mL	Yes
2-Deoxy-D-Glucose	Human	Urine	LC/MS/MS	N/A	0.1 mL	1-200 µg/mL	Yes
4-Hydroxy Tolbutamide	Human	Plasma	LC/MS/MS	EDTA	0.02 mL	10.0 - 5,000 ng/mL	Yes
5-Amino Salicylic acid N-Acetyl-5-ASA	Rabbit	Plasma	HPLC/UV	Sodium Citrate	0.1 mL	50-5,000 ng/mL	No
5-Amino Salicylic acid N-Acetyl-5-ASA	Dog	Plasma	HPLC/UV	Sodium Citrate	0.1 mL	50-5,000 ng/mL	No
5-Amino Salicylic acid N-Acetyl-5-ASA	Rabbit	Plasma	LC/MS/MS	EDTA	0.025 mL	25-10,000 ng/mL 50-20,000 ng/mL	Yes
5-Amino Salicylic acid N-Acetyl-5-ASA	Dog	Plasma	LC/MS/MS	EDTA	0.025 mL	50-25,000 ng/mL 25-12,500 ng/mL	Yes
5-Fluorouracil	Human	Plasma	LC/MS/MS	Heparin	0.05 mL	5-2,500 ng/mL	Yes
5-Methyltetrahydrofolate (6R/6S)	Human	Plasma	LC/MS/MS	Heparin	0.1 mL	10.0 - 10,000 ng/mL	Yes
17-alpha Hydroxypregnenolone	Rat/Dog	Plasma	LC/MS/MS	EDTA	0.05 mL	0.100 - 50.0 ng/mL	Yes
17-alpha Hydroxyprogesterone	Rat/Dog	Plasma	LC/MS/MS	EDTA	0.05 mL	0.0500 - 25.0 ng/mL	Yes
25-Desacetyl Rifaximin	Human	Plasma	LC/MS/MS	Heparin	0.05 mL	0.100 - 25.0 ng/mL	Yes
Acetaminophen	Human	Plasma	HPLC/UV	Heparin	0.1 mL	0.5-50 µg/mL	No
Adapalene	Human	Plasma	LC/FLD	EDTA	0.1 mL	0.250 - 25.0 ng/mL	No
Allopurinol	Human	Serum	LC/MS/MS	N/A	0.025 mL	0.0500 - 10 ug/mL	Yes
Alogliptin	Human	Plasma	LC/MS/MS	EDTA	0.2 mL	0.500 - 200 ng/mL	Yes
Alprazolam α-OH-Alprazolam 4-OH-Alprazolam	Human	Plasma	LC/MS/MS	EDTA	0.050 mL	0.100-100 ng/mL	Yes
Amitriptyline Nortriptyline	Human	Plasma	LC/MS/MS	Heparin	0.1 mL	0.25-250 ng/mL	Yes
Anandamide	Human	Plasma	LC/MS/MS	Heparin	0.1 mL	0.1-5 ng/mL	Yes
Anastrozole	Human	Plasma	LC/MS/MS	Heparin	0.1 mL	1-100 ng/mL	Yes
Aplindore	Human	Plasma	LC/MS/MS	Heparin	0.5 mL	10-5,000 pg/mL	Yes
Atorvastatin p-hydroxyatorvastatin o-hydroxyatrovastatin	Human	Plasma	LC/MS/MS	EDTA or Heparin	0.05 mL	0.1-20 ng/mL	Yes
BDNF	Human	Serum	ELISA	N/A	0.02 mL	0.350 - 4.80 ng/mL	N/A
Benzoic acid	Minipig	Plasma	HPLC/UV	EDTA	0.1 mL	50-2,000 ng/mL	No
Benzoylecgonine	Human	Plasma	LC/MS/MS	Heparin	0.2 mL	25-10,000 ng/mL	Yes
Benzyl alcohol	Human	Plasma	HPLC/UV	EDTA	0.1 mL	1-100 µg/mL	No
Besifloxacin	Human	Plasma	LC/MS/MS	EDTA	0.05 mL	0.0500 - 50.0 ng/mL	Yes
Bromfenac	Human	Serum	HPLC/UV	N/A	0.25 mL	50-10,000 ng/mL	No
Budesonide	Human	Plasma	LC/MS/MS	EDTA	0.4 mL	10.0 - 2,000 pg/mL	Yes
Caffeine 1,7-dimethylxanthine	Human	Plasma	LC/MS/MS	Heparin	0.1 mL	100-50,000 ng/mL 50-25,000 ng/mL	No
Caffeine 1,7-dimethylxanthine	Human	Urine	LC/MS/MS	N/A	0.1 mL	500-25,000 ng/mL	No
Calcipotriene	Human	Plasma	LC/MS/MS	Heparin	1.0 mL	10-2,000 pg/mL	No
cAMP	Human	Plasma	LC/MS/MS	EDTA	0.025 mL	2.00 - 200 ng/mL	No
Campesterol ß-Sitosterol Campestanol Sitostanol	Human	Plasma	LC/MS/MS	EDTA	0.1 mL	1,000-8,800 ng/mL 1,000-13,400 ng/mL 4-1,000 ng/mL 5-1,700 ng/mL	Yes
Carbamazepine	Human	Plasma	LC/MS/MS	Citrate	0.08 mL	5.00 - 1,000 ng/mL	Yes
Carboxyethylphosphoramide mustard (CEPM)	Human	Plasma	LC/MS/MS	Heparin	0.05 mL	0.05-50 µg/mL	Yes
Cephalothin	Rat	Plasma	HPLC/UV	Heparin	0.1 mL	0.5-50 µg/mL	No
Cetylpyridinium	Human	Plasma	LC/MS/MS	Heparin	0.1 mL	1-200 ng/mL	Yes
cGMP	Human	Plasma	LC/MS/MS	EDTA	0.05 mL	1.00 - 1,000 ng/mL	Yes
cGMP	Human	Urine	LC/MS/MS	N/A	0.02 mL	5.00 - 5,000 ng/mL	Yes
cGMP	Human	CSF	LC/MS/MS	N/A	0.2 mL	0.100 - 20.0 ng/mL	Yes
Chloroadenine	Human	Plasma	LC/MS/MS	Heparin	0.1 mL	1-500 ng/mL	No
Cimetidine	Human	Plasma	LC/MS/MS	EDTA or Heparin	0.05 mL	5-5,000 ng/mL	Yes
Ciprofloxacin	Human	Plasma	LC/MS/MS	EDTA	0.2 mL	1.87 - 935 ng/mL	Yes
Cisplatin	Human	Plasma	LC/MS/MS	Heparin	0.05 mL	20.0 - 5,000 ng/mL	No
Citrulline	Rat	Plasma	LC/MS/MS	Heparin	0.1 mL	2-200 µg/mL	No
Clindamycin Clindamycin sulfoxide	Human	Plasma	LC/MS/MS	EDTA	0.05 mL	50-20,000 pg/mL	No
Clobetasol propionate	Human	Plasma	LC/MS/MS	EDTA	0.4 mL	20-10,000 pg/mL	No
Clofarabine	Human	Plasma	LC/MS/MS	Heparin	0.2 mL	0.100 - 50.0 ng/mL	No
Clozapine	Human	Plasma	LC/MS/MS	Heparin	0.05 mL	0.2-200 ng/mL	Yes
Cocaine Norcocaine Cocaethylene	Human	Plasma	LC/MS/MS	Heparin	0.2 mL	25-10,000 ng/mL	Yes
Cordycepin	Human	Whole Blood	LC/MS/MS	EDTA	0.05 mL	0.1-10 µg/mL	Yes
Cortisol	Rat/Dog	Plasma	LC/MS/MS	EDTA	0.05 mL	1.00 - 500 ng/mL	Yes
Cortisol 6ß-hydroxycortisol	Human	Urine	LC/MS/MS	N/A	1.0 mL	5-250 ng/mL 50-2,500 ng/mL	No
Cytarabine	Human	Plasma	LC/MS/MS	EDTA	0.05 mL	2-500 ng/mL	Yes
Daunorubicin Daunorubicinol	Human	Plasma	LC/MS/MS	EDTA	0.1 mL	1-1,000 ng/mL 0.2-200 ng/mL	Yes
Dehydroepiandrosterone	Rat/Dog	Plasma	LC/MS/MS	EDTA	0.05 mL	0.100 - 50.0 ng/mL	Yes
Diclofenac	Human	Plasma	LC/MS/MS	Heparin	0.1 mL	1-1,000 ng/mL	Yes
Digoxin	Human	Plasma	LC/MS/MS	Heparin	0.2 mL	0.1-10 ng/mL	Yes
Docetaxel	Human	Plasma	LC/MS/MS	Heparin	0.25 mL	0.5-100 ng/mL	Yes
Dopamine	Human	Plasma	LC/MS/MS	EDTA	0.2 mL	2.00 - 400 pg/mL	Yes
Dopamine	Human	CSF	LC/MS/MS	N/A	0.2 mL	2.00 - 400 pg/mL	Yes
Doxycycline	Human	Plasma	LC/MS/MS	Heparin	0.05 mL	10.0 - 4,000 ng/mL	No
Econazole	Human	Plasma	HPLC/UV	Heparin	1.0 mL	20-1,000 ng/mL 20-1,000 ng/mL	No
Econazole	Human	Plasma	LC/MS/MS	EDTA	0.2 mL	100-50,000 pg/mL	No
Erlotinib	Human	Plasma	LC/MS/MS	Heparin	0.025 mL	10-10,000 ng/mL	Yes
Ethinyl estradiol	Human	Plasma	LC/MS/MS	Heparin	0.5 mL	2-500 pg/mL	Yes
Etoposide	Human	Plasma	LC/MS/MS	Heparin	0.02 mL	0.100-100 µg/mL	Yes
Fentanyl	Human	Plasma	LC/MS/MS	Heparin	0.1 mL	50-20,000 pg/mL	No
Finasteride	Human	Plasma	LC/MS/MS	EDTA	0.025 mL	20.0 - 50,000 ng/mL	Yes
Fludarabine desphosphate	Human	Plasma	LC/MS/MS	Heparin	0.1 mL	0.5-500 ng/mL	No
Fluticasone Propionate	Human	Plasma	LC/MS/MS	EDTA	1.0 mL	0.250 - 50.0 pg/mL	Yes
Ganaxolone	Human	Plasma	LC/MS/MS	EDTA	0.2 mL	5-1,500 ng/mL	No
Gefitinib	Human	Plasma	LC/MS/MS	Heparin	0.05 mL	5-1,000 ng/mL	Yes
Gemcitabine	Human	Plasma	LC/MS/MS	Heparin	0.05 mL	10-10,000 ng/mL	Yes
Gemfibrozil	Human	Plasma	LC/MS/MS	Heparin	0.025 mL	0.1-500 µg/mL	Yes
Gentamicin	Human	Plasma	LC/MS/MS	Heparin	0.05 mL	2-5,000 ng/mL	Yes
Glimepiride	Human	Plasma	LC/MS/MS	Heparin	0.05 mL	2-2,000 ng/mL	Yes
Glyburide	Human	Plasma	LC/MS/MS	EDTA or Heparin	0.1 mL	1-500 ng/mL	No
Herceptin	Human	Plasma	MSD	K3EDTA	0.025 mL	0.137-100 µg/mL	No
Histamine N-methylhistamine	Human	Plasma	LC/MS/MS	EDTA	0.5 mL	0.2-50 ng/mL	Yes
Histamine N-methylhistamine	Human	Urine	LC/MS/MS	N/A	0.05 mL	10-2,000 ng/mL 50-10,000 ng/mL	Yes
Hydroxy Itraconazole	Human	Plasma	LC/MS/MS	Heparin	0.05 mL	20.0 - 2,000 ng/mL	Yes
Hydroxy Pioglitazone (M-IV)	Human	Plasma	LC/MS/MS	EDTA	0.05 mL	0.500 - 500 ng/mL	Yes
Indomethacin	Human	Plasma	LC/MS/MS	EDTA	0.02 mL	20-4,000 ng/mL	Yes
Itraconazole	Human	Plasma	LC/MS/MS	Heparin	0.05 mL	20.0 - 2,000 ng/mL	Yes
Ketoconazole	Human	Plasma	LC/MS/MS	EDTA	0.05 mL	5-5,000 ng/mL	Yes
Lamotrigine	Human	Plasma	LC/MS/MS	Heparin	0.025 mL	0.025-25 µg/mL	Yes
L-Arginine	Human	Plasma	HPLC/UV	Heparin	0.125 mL	1-250 µg/mL	No
Leucovorin (6R/6S)	Human	Plasma	LC/MS/MS	Heparin	0.1 mL	10.0 - 10,000 ng/mL	Yes
Levetiracetam	Human	Plasma	LC/MS/MS	EDTA	0.1 mL	100 - 50,000 ng/mL	Yes
Levofloxacin	Human	Plasma	LC/MS/MS	Heparin	0.025 mL	10-10,000 ng/mL	Yes
Lidocaine	Human	Plasma	LC/MS/MS	Heparin	0.1 mL	0.2-100 ng/mL	No
Lidocaine	Human	Plasma	LC/MS/MS	EDTA	0.1 mL	0.2-100 ng/mL	Yes
Lidocaine 2,6 - dimethylaniline Monoethylglycinexylidide Glycinexylidide	Human	Plasma	LC/MS/MS	EDTA or Heparin	0.1 mL	0.2-200 ng/mL 1-1,000 ng/mL	Yes
L-Methionine	Human	Plasma	LC/MS/MS	Heparin	0.1 mL	1-200 µg/mL	Yes
Lucanthone Hycanthone	Human	Plasma	LC/MS/MS	Heparin	0.05 mL	1-200 ng/mL	Yes
Metformin	Human	Plasma	LC/MS/MS	Heparin	0.05 mL	10-2,000 ng/mL	Yes
Methotrexate	Human	Plasma	LC/MS/MS	Heparin	0.05 mL	1-1,000 ng/mL	Yes
Metoprolol	Human	Plasma	LC/MS/MS	EDTA	0.05 mL	1.00 - 500 ng/mL	Yes
Midazolam	Human	Plasma	LC/MS/MS	EDTA	0.1 mL	0.5-250 ng/mL	No
Midazolam 1-hydroxymidazolam	Human	Plasma	LC/MS/MS	EDTA	0.1 mL	0.5-100 ng/mL	Yes
Mifepristone	Human	Plasma	LC/MS/MS	Heparin	0.05 mL	10-2,000 ng/mL	Yes
Mifepristone	Human	Plasma	LC/MS/MS	EDTA or Heparin	0.05 mL	100 - 10,000 ng/mL	Yes
Minocycline	Human	Plasma	LC/MS/MS	Heparin	0.05 mL	10.0 - 4,000 ng/mL	Yes
Minocycline	Human	Plasma	LC/MS/MS	Heparin	0.05 mL	10.0 - 4,000 ng/mL	Yes
Mitiglinide	Human	Plasma	LC/MS/MS	Heparin	0.1 mL	1-1,000 ng/mL	No
Mitomycin	Human	Plasma	LC/MS/MS	EDTA	0.05 mL	10-5,000 ng/mL	No
Morphine Morphine-6-ß-D-glucuronide	Human	Plasma	LC/MS/MS	Heparin	0.1 mL	0.5-500 ng/mL	Yes
Moxifloxacin	Human	Plasma	LC/MS/MS	EDTA	0.025 mL	10.0 - 5,000 ng/mL	Yes
Nabilone	Human	Plasma	LC/MS/MS	Heparin	0.5 mL	100-20,000 pg/mL	No
N-acetylcysteine	Dog	Plasma	LC/MS/MS	EDTA	0.025 mL	1-1,000 µg/mL	Yes
N-acetylcysteine	Rabbit	Plasma	LC/MS/MS	EDTA	0.025 mL	1-1,000 µg/mL	Yes
Nalbuphine	Human	Plasma	LC/MS/MS	Heparin	0.25 mL	0.1-50 ng/mL	No
Naloxone	Human	Plasma	LC/MS/MS	Heparin	0.25 mL	0.1-50 ng/mL	No
Naproxen	Human	Plasma	LC/MS/MS	Heparin	0.025 mL	0.100-100 µg/mL	Yes
Nifuratel	Human	Plasma	LC/MS/MS	Heparin	0.1 mL	1.00 - 200 ng/mL	No
Nintedanib	Human	Plasma	LC/MS/MS	EDTA	0.05 mL	0.0500 - 50.0 ng/mL	Yes
Nitedanib Carboxylic aicd	Human	Plasma	LC/MS/MS	EDTA	0.05 mL	0.0500 - 50.0 ng/mL	Yes
Norethindrone	Human	Plasma	LC/MS/MS	Heparin	0.25 mL	20-10,000 pg/mL	Yes
Norflaxacin	Human	Plasma	LC/MS/MS	EDTA	0.1 mL	10.0 - 1,000 ng/mL	Yes
Norgestrel 17-deacetylnorgestimate	Human	Plasma	LC/MS/MS	Heparin	0.25 mL	40-20,000 pg/mL 20-10,000 pg/mL	Yes
Omeprazole	Human	Plasma	LC/MS/MS	EDTA	0.05 mL	1.00 - 1,000 ng/mL	Yes
Omeprazole sulfone	Human	Plasma	LC/MS/MS	EDTA	0.05 mL	0.500 - 500 ng/mL	Yes
Ondansetron	Human	Plasma	LC/MS/MS	Heparin	0.05 mL	0.5-250 ng/mL	Yes
Oxybutynin	Human	Plasma	LC/MS/MS	Heparin	0.4 mL	0.0500 - 25.0 ng/mL	Yes
Oxycodone	Human	Plasma	LC/MS/MS	EDTA or Heparin	0.1 mL	0.2-50 ng/mL	Yes
Oxycodone Oxymorphone Noroxycodone	Human	Plasma	LC/MS/MS	Heparin	0.5 mL	0.05-25 ng/mL	Yes
Oxypurinol	Human	Serum	LC/MS/MS	N/A	0.025 mL	0.100 - 20.0 ug/mL	Yes
Paclitaxel	Human	Plasma	LC/MS/MS	EDTA or Heparin	0.1 mL	0.5-200 ng/mL	No
Pioglitazone	Human	Plasma	LC/MS/MS	EDTA	0.05 mL	1.00 - 1,000 ng/mL	Yes
Piperacillin	Human	Plasma	LC/MS/MS	Heparin	0.025 mL	0.0500 - 50.0 ug/mL	No
Piperacillin	Human	ELF	LC/MS/MS	N/A	0.8 mL	1.00 - 500 ng/mL	No
Prednisolone	Human	Plasma	LC/MS/MS	Heparin	0.1 mL	1.00 - 1,000 ng/mL	Yes
Prednisone	Human	Plasma	LC/MS/MS	Heparin	0.1 mL	1.00 - 1,000 ng/mL	Yes
Prilocaine	Human	Plasma	LC/MS/MS	EDTA	0.05 mL	0.2-100 ng/mL	No
Promethazine	Human	Plasma	LC/MS/MS	Heparin	0.1 mL	0.2-100 ng/mL	No
Quetiapine	Human	Plasma	LC/MS/MS	EDTA or Heparin	0.05 mL	1-1,000 ng/mL	Yes
Repaglinide	Human	Plasma	LC/MS/MS	EDTA	0.05 mL	0.1-100 ng/mL	Yes
Repaglinide	Human	Plasma	LC/MS/MS	EDTA	0.05 mL	0.100 - 100 ng/mL	Yes
Repaglinide	Human	Plasma	LC/MS/MS	Heparin	0.2 mL	0.100 - 100 ng/mL	Yes
Ribavirin	Human	Plasma	LC/MS/MS	Heparin	0.05 mL	5.00 - 2,500 ng/mL	Yes
Riboflavin Riboflavin 5-phosphate	Dog	Plasma	Fluorescence	Heparin	0.05 mL	20-10,000 ng/mL 40-20,000 ng/mL	No
Riboflavin Riboflavin 5-phosphate	Rat	Plasma	Fluorescence	Heparin	0.05 mL	20-10,000 ng/mL 40-20,000 ng/mL	No
Rifampin 25-desacetylrifampin	Human	Plasma	LC/MS/MS	EDTA	0.05 mL	0.1-20 µg/mL	Yes
Rifaximin	Human	Plasma	LC/MS/MS	Heparin	0.05 mL	0.100 - 25.0 ng/mL	Yes
Rifaximin	Human	Urine	LC/MS/MS	N/A	0.5 mL	0.200 - 100 ng/mL	Yes
Riluzole	Human	Serum	LC/MS/MS	N/A	0.1 mL	1-500 ng/mL	No
Risperidone 9- hydroxyrisperidone	Human	Plasma	LC/MS/MS	Heparin	0.05 mL	0.1-100 ng/mL	Yes
Ropivacaine	Human	Plasma	LC/MS/MS	Heparin	0.02 mL	1.00 - 1,000 ng/mL	Yes
Rosuvastatin n-desmethyl rosuvastatin	Human	Plasma	LC/MS/MS	Heparin	0.1 mL	0.1-50 ng/mL	Yes
Simvastatin Simvastatin hydroxy acid	Human	Plasma	LC/MS/MS	Heparin	0.25 mL	0.05-50 ng/mL	Yes
Sitagliptin	Human	Plasma	LC/MS/MS	Heparin	0.2 mL	0.500 - 1,000 ng/mL	Yes
Sorafenib	Human	Plasma	LC/MS/MS	EDTA	0.05 mL	10-10,000 ng/mL	Yes
Sumatriptan	Human	Plasma	LC/MS/MS	Heparin	0.1 mL	1-200 ng/mL	No
Tazobactam	Human	Plasma	LC/MS/MS	Heparin	0.02 mL	0.100 - 60.0 ug/mL	No
Tazobactam	Human	ELF	LC/MS/MS	N/A	0.02 mL	1.00 - 250 ng/mL	No
Tazobactam M1	Human	Plasma	LC/MS/MS	Heparin	0.02 mL	0.0500 - 30.0 ug/mL	No
Tenofovir	Human	Plasma	LC/MS/MS	Heparin	0.1 mL	2.00 - 1,000 ng/mL	Yes
Tolbutamide	Human	Plasma	LC/MS/MS	EDTA	0.1 mL	0.1-20 µg/mL	No
Tolbutamide	Human	Plasma	LC/MS/MS	EDTA	0.02 mL	100 - 50,000 ng/mL	Yes
Tolbutamide 4-hydroxytolbutamide	Human	Urine	LC/MS/MS	N/A	0.1 mL	0.1-20 µg/mL	No
Trazodone	Human	Plasma	LC/MS/MS	Heparin	0.05 mL	0.2-200 ng/mL	Yes
Tretinoin	Human	Plasma	LC/MS/MS	EDTA	0.2 mL	0.4-10 ng/mL	Yes
Trimetazidine	Human	Plasma	LC/MS/MS	Heparin	0.2 mL	0.200 - 100 ng/mL	Yes
Urea	Human	Plasma	Colorimetric	EDTA	0.01 mL	2.50 - 50.0 mg/dL	N/A
Urea	Human	ELF	Colorimetric	N/A	0.3 mL	0.0500 - 1.00 mg/dL	N/A
Valerenic acid Hydroxyvalerenic acid Acetoxyvalerenic acid	Human	Plasma	LC/MS/MS	Heparin	0.2 mL	1-500 ng/mL	No
Vancomycin	Human	Plasma	LC/MS/MS	Heparin	0.02 mL	50-25,000 ng/mL	No
Vidagliptin	Human	Plasma	LC/MS/MS	Heparin	0.2 mL	0.500 - 500 ng/mL	Yes
Voruciclib	Human	Plasma	LC/MS/MS	EDTA	0.1 mL	5.00 - 2,000 ng/mL	Yes
Warfarin (R-)	Human	Plasma	LC/MS/MS	Heparin	0.025 mL	2-2,000 ng/mL	Yes
Warfarin (S-)	Human	Plasma	LC/MS/MS	Heparin	0.025 mL	2-2,000 ng/mL	Yes
Yohimbine	Human	Plasma	LC/MS/MS	EDTA	0.1 mL	0.1-50 ng/mL	No
Zolpidem	Human	Plasma	LC/MS/MS	EDTA	0.05 mL	1-150 ng/mL	Yes
Zolpidem	Baboon	Plasma	LC/MS/MS	EDTA	0.05 mL	1-1,000 ng/mL	Yes

Drug

Species

Matrix

Technique

Anticoagulant

Extraction Volume

Range

Stable Labeled I.S.

2-Deoxy-D-Glucose

Human

Plasma

LC/MS/MS

Heparin

0.1 mL

0.25-50 µg/mL

Yes

2-Deoxy-D-Glucose

Human

Urine

LC/MS/MS

N/A

0.1 mL

1-200 µg/mL

Yes

4-Hydroxy Tolbutamide

Human

Plasma

LC/MS/MS

EDTA

0.02 mL

10.0 - 5,000 ng/mL

Yes

5-Amino Salicylic acid
N-Acetyl-5-ASA

Rabbit

Plasma

HPLC/UV

Sodium Citrate

0.1 mL

50-5,000 ng/mL

5-Amino Salicylic acid
N-Acetyl-5-ASA

Dog

Plasma

HPLC/UV

Sodium Citrate

0.1 mL

50-5,000 ng/mL

5-Amino Salicylic acid
N-Acetyl-5-ASA

Rabbit

Plasma

LC/MS/MS

EDTA

0.025 mL

25-10,000 ng/mL
50-20,000 ng/mL

Yes

5-Amino Salicylic acid
N-Acetyl-5-ASA

Dog

Plasma

LC/MS/MS

EDTA

0.025 mL

50-25,000 ng/mL
25-12,500 ng/mL

Yes

5-Fluorouracil

Human

Plasma

LC/MS/MS

Heparin

0.05 mL

5-2,500 ng/mL

Yes

5-Methyltetrahydrofolate (6R/6S)

Human

Plasma

LC/MS/MS

Heparin

0.1 mL

10.0 - 10,000 ng/mL

Yes

17-alpha Hydroxypregnenolone

Rat/Dog

Plasma

LC/MS/MS

EDTA

0.05 mL

0.100 - 50.0 ng/mL

Yes

17-alpha Hydroxyprogesterone

Rat/Dog

Plasma

LC/MS/MS

EDTA

0.05 mL

0.0500 - 25.0 ng/mL

Yes

25-Desacetyl Rifaximin

Human

Plasma

LC/MS/MS

Heparin

0.05 mL

0.100 - 25.0 ng/mL

Yes

Acetaminophen

Human

Plasma

HPLC/UV

Heparin

0.1 mL

0.5-50 µg/mL

Adapalene

Human

Plasma

LC/FLD

EDTA

0.1 mL

0.250 - 25.0 ng/mL

Allopurinol

Human

Serum

LC/MS/MS

N/A

0.025 mL

0.0500 - 10 ug/mL

Yes

Alogliptin

Human

Plasma

LC/MS/MS

EDTA

0.2 mL

0.500 - 200 ng/mL

Yes

Alprazolam
α-OH-Alprazolam
4-OH-Alprazolam

Human

Plasma

LC/MS/MS

EDTA

0.050 mL

0.100-100 ng/mL

Yes

Amitriptyline
Nortriptyline

Human

Plasma

LC/MS/MS

Heparin

0.1 mL

0.25-250 ng/mL

Yes

Anandamide

Human

Plasma

LC/MS/MS

Heparin

0.1 mL

0.1-5 ng/mL

Yes

Anastrozole

Human

Plasma

LC/MS/MS

Heparin

0.1 mL

1-100 ng/mL

Yes

Aplindore

Human

Plasma

LC/MS/MS

Heparin

0.5 mL

10-5,000 pg/mL

Yes

Atorvastatin
p-hydroxyatorvastatin
o-hydroxyatrovastatin

Human

Plasma

LC/MS/MS

EDTA or Heparin

0.05 mL

0.1-20 ng/mL

Yes

BDNF

Human

Serum

ELISA

N/A

0.02 mL

0.350 - 4.80 ng/mL

N/A

Benzoic acid

Minipig

Plasma

HPLC/UV

EDTA

0.1 mL

50-2,000 ng/mL

Benzoylecgonine

Human

Plasma

LC/MS/MS

Heparin

0.2 mL

25-10,000 ng/mL

Yes

Benzyl alcohol

Human

Plasma

HPLC/UV

EDTA

0.1 mL

1-100 µg/mL

Besifloxacin

Human

Plasma

LC/MS/MS

EDTA

0.05 mL

0.0500 - 50.0 ng/mL

Yes

Bromfenac

Human

Serum

HPLC/UV

N/A

0.25 mL

50-10,000 ng/mL

Budesonide

Human

Plasma

LC/MS/MS

EDTA

0.4 mL

10.0 - 2,000 pg/mL

Yes

Caffeine
1,7-dimethylxanthine

Human

Plasma

LC/MS/MS

Heparin

0.1 mL

100-50,000 ng/mL
50-25,000 ng/mL

Caffeine
1,7-dimethylxanthine

Human

Urine

LC/MS/MS

N/A

0.1 mL

500-25,000 ng/mL

Calcipotriene

Human

Plasma

LC/MS/MS

Heparin

1.0 mL

10-2,000 pg/mL

cAMP

Human

Plasma

LC/MS/MS

EDTA

0.025 mL

2.00 - 200 ng/mL

Campesterol
ß-Sitosterol
Campestanol
Sitostanol

Human

Plasma

LC/MS/MS

EDTA

0.1 mL

1,000-8,800 ng/mL
1,000-13,400 ng/mL
4-1,000 ng/mL
5-1,700 ng/mL

Yes

Carbamazepine

Human

Plasma

LC/MS/MS

Citrate

0.08 mL

5.00 - 1,000 ng/mL

Yes

Carboxyethylphosphoramide mustard (CEPM)

Human

Plasma

LC/MS/MS

Heparin

0.05 mL

0.05-50 µg/mL

Yes

Cephalothin

Rat

Plasma

HPLC/UV

Heparin

0.1 mL

0.5-50 µg/mL

Cetylpyridinium

Human

Plasma

LC/MS/MS

Heparin

0.1 mL

1-200 ng/mL

Yes

cGMP

Human

Plasma

LC/MS/MS

EDTA

0.05 mL

1.00 - 1,000 ng/mL

Yes

cGMP

Human

Urine

LC/MS/MS

N/A

0.02 mL

5.00 - 5,000 ng/mL

Yes

cGMP

Human

CSF

LC/MS/MS

N/A

0.2 mL

0.100 - 20.0 ng/mL

Yes

Chloroadenine

Human

Plasma

LC/MS/MS

Heparin

0.1 mL

1-500 ng/mL

Cimetidine

Human

Plasma

LC/MS/MS

EDTA or Heparin

0.05 mL

5-5,000 ng/mL

Yes

Ciprofloxacin

Human

Plasma

LC/MS/MS

EDTA

0.2 mL

1.87 - 935 ng/mL

Yes

Cisplatin

Human

Plasma

LC/MS/MS

Heparin

0.05 mL

20.0 - 5,000 ng/mL

Citrulline

Rat

Plasma

LC/MS/MS

Heparin

0.1 mL

2-200 µg/mL

Clindamycin
Clindamycin sulfoxide

Human

Plasma

LC/MS/MS

EDTA

0.05 mL

50-20,000 pg/mL

Clobetasol propionate

Human

Plasma

LC/MS/MS

EDTA

0.4 mL

20-10,000 pg/mL

Clofarabine

Human

Plasma

LC/MS/MS

Heparin

0.2 mL

0.100 - 50.0 ng/mL

Clozapine

Human

Plasma

LC/MS/MS

Heparin

0.05 mL

0.2-200 ng/mL

Yes

Cocaine
Norcocaine
Cocaethylene

Human

Plasma

LC/MS/MS

Heparin

0.2 mL

25-10,000 ng/mL

Yes

Cordycepin

Human

Whole Blood

LC/MS/MS

EDTA

0.05 mL

0.1-10 µg/mL

Yes

Cortisol

Rat/Dog

Plasma

LC/MS/MS

EDTA

0.05 mL

1.00 - 500 ng/mL

Yes

Cortisol
6ß-hydroxycortisol

Human

Urine

LC/MS/MS

N/A

1.0 mL

5-250 ng/mL
50-2,500 ng/mL

Cytarabine

Human

Plasma

LC/MS/MS

EDTA

0.05 mL

2-500 ng/mL

Yes

Daunorubicin
Daunorubicinol

Human

Plasma

LC/MS/MS

EDTA

0.1 mL

1-1,000 ng/mL
0.2-200 ng/mL

Yes

Dehydroepiandrosterone

Rat/Dog

Plasma

LC/MS/MS

EDTA

0.05 mL

0.100 - 50.0 ng/mL

Yes

Diclofenac

Human

Plasma

LC/MS/MS

Heparin

0.1 mL

1-1,000 ng/mL

Yes

Digoxin

Human

Plasma

LC/MS/MS

Heparin

0.2 mL

0.1-10 ng/mL

Yes

Docetaxel

Human

Plasma

LC/MS/MS

Heparin

0.25 mL

0.5-100 ng/mL

Yes

Dopamine

Human

Plasma

LC/MS/MS

EDTA

0.2 mL

2.00 - 400 pg/mL

Yes

Dopamine

Human

CSF

LC/MS/MS

N/A

0.2 mL

2.00 - 400 pg/mL

Yes

Doxycycline

Human

Plasma

LC/MS/MS

Heparin

0.05 mL

10.0 - 4,000 ng/mL

Econazole

Human

Plasma

HPLC/UV

Heparin

1.0 mL

20-1,000 ng/mL
20-1,000 ng/mL

Econazole

Human

Plasma

LC/MS/MS

EDTA

0.2 mL

100-50,000 pg/mL

Erlotinib

Human

Plasma

LC/MS/MS

Heparin

0.025 mL

10-10,000 ng/mL

Yes

Ethinyl estradiol

Human

Plasma

LC/MS/MS

Heparin

0.5 mL

2-500 pg/mL

Yes

Etoposide

Human

Plasma

LC/MS/MS

Heparin

0.02 mL

0.100-100 µg/mL

Yes

Fentanyl

Human

Plasma

LC/MS/MS

Heparin

0.1 mL

50-20,000 pg/mL

Finasteride

Human

Plasma

LC/MS/MS

EDTA

0.025 mL

20.0 - 50,000 ng/mL

Yes

Fludarabine desphosphate

Human

Plasma

LC/MS/MS

Heparin

0.1 mL

0.5-500 ng/mL

Fluticasone Propionate

Human

Plasma

LC/MS/MS

EDTA

1.0 mL

0.250 - 50.0 pg/mL

Yes

Ganaxolone

Human

Plasma

LC/MS/MS

EDTA

0.2 mL

5-1,500 ng/mL

Gefitinib

Human

Plasma

LC/MS/MS

Heparin

0.05 mL

5-1,000 ng/mL

Yes

Gemcitabine

Human

Plasma

LC/MS/MS

Heparin

0.05 mL

10-10,000 ng/mL

Yes

Gemfibrozil

Human

Plasma

LC/MS/MS

Heparin

0.025 mL

0.1-500 µg/mL

Yes

Gentamicin

Human

Plasma

LC/MS/MS

Heparin

0.05 mL

2-5,000 ng/mL

Yes

Glimepiride

Human

Plasma

LC/MS/MS

Heparin

0.05 mL

2-2,000 ng/mL

Yes

Glyburide

Human

Plasma

LC/MS/MS

EDTA or Heparin

0.1 mL

1-500 ng/mL

Herceptin

Human

Plasma

MSD

K3EDTA

0.025 mL

0.137-100 µg/mL

Histamine
N-methylhistamine

Human

Plasma

LC/MS/MS

EDTA

0.5 mL

0.2-50 ng/mL

Yes

Histamine
N-methylhistamine

Human

Urine

LC/MS/MS

N/A

0.05 mL

10-2,000 ng/mL
50-10,000 ng/mL

Yes

Hydroxy Itraconazole

Human

Plasma

LC/MS/MS

Heparin

0.05 mL

20.0 - 2,000 ng/mL

Yes

Hydroxy Pioglitazone (M-IV)

Human

Plasma

LC/MS/MS

EDTA

0.05 mL

0.500 - 500 ng/mL

Yes

Indomethacin

Human

Plasma

LC/MS/MS

EDTA

0.02 mL

20-4,000 ng/mL

Yes

Itraconazole

Human

Plasma

LC/MS/MS

Heparin

0.05 mL

20.0 - 2,000 ng/mL

Yes

Ketoconazole

Human

Plasma

LC/MS/MS

EDTA

0.05 mL

5-5,000 ng/mL

Yes

Lamotrigine

Human

Plasma

LC/MS/MS

Heparin

0.025 mL

0.025-25 µg/mL

Yes

L-Arginine

Human

Plasma

HPLC/UV

Heparin

0.125 mL

1-250 µg/mL

Leucovorin (6R/6S)

Human

Plasma

LC/MS/MS

Heparin

0.1 mL

10.0 - 10,000 ng/mL

Yes

Levetiracetam

Human

Plasma

LC/MS/MS

EDTA

0.1 mL

100 - 50,000 ng/mL

Yes

Levofloxacin

Human

Plasma

LC/MS/MS

Heparin

0.025 mL

10-10,000 ng/mL

Yes

Lidocaine

Human

Plasma

LC/MS/MS

Heparin

0.1 mL

0.2-100 ng/mL

Lidocaine

Human

Plasma

LC/MS/MS

EDTA

0.1 mL

0.2-100 ng/mL

Yes

Lidocaine
2,6 - dimethylaniline
Monoethylglycinexylidide
Glycinexylidide

Human

Plasma

LC/MS/MS

EDTA or Heparin

0.1 mL

0.2-200 ng/mL
1-1,000 ng/mL

Yes

L-Methionine

Human

Plasma

LC/MS/MS

Heparin

0.1 mL

1-200 µg/mL

Yes

Lucanthone
Hycanthone

Human

Plasma

LC/MS/MS

Heparin

0.05 mL

1-200 ng/mL

Yes

Metformin

Human

Plasma

LC/MS/MS

Heparin

0.05 mL

10-2,000 ng/mL

Yes

Methotrexate

Human

Plasma

LC/MS/MS

Heparin

0.05 mL

1-1,000 ng/mL

Yes

Metoprolol

Human

Plasma

LC/MS/MS

EDTA

0.05 mL

1.00 - 500 ng/mL

Yes

Midazolam

Human

Plasma

LC/MS/MS

EDTA

0.1 mL

0.5-250 ng/mL

Midazolam
1-hydroxymidazolam

Human

Plasma

LC/MS/MS

EDTA

0.1 mL

0.5-100 ng/mL

Yes

Mifepristone

Human

Plasma

LC/MS/MS

Heparin

0.05 mL

10-2,000 ng/mL

Yes

Mifepristone

Human

Plasma

LC/MS/MS

EDTA or Heparin

0.05 mL

100 - 10,000 ng/mL

Yes

Minocycline

Human

Plasma

LC/MS/MS

Heparin

0.05 mL

10.0 - 4,000 ng/mL

Yes

Minocycline

Human

Plasma

LC/MS/MS

Heparin

0.05 mL

10.0 - 4,000 ng/mL

Yes

Mitiglinide

Human

Plasma

LC/MS/MS

Heparin

0.1 mL

1-1,000 ng/mL

Mitomycin

Human

Plasma

LC/MS/MS

EDTA

0.05 mL

10-5,000 ng/mL

Morphine
Morphine-6-ß-D-glucuronide

Human

Plasma

LC/MS/MS

Heparin

0.1 mL

0.5-500 ng/mL

Yes

Moxifloxacin

Human

Plasma

LC/MS/MS

EDTA

0.025 mL

10.0 - 5,000 ng/mL

Yes

Nabilone

Human

Plasma

LC/MS/MS

Heparin

0.5 mL

100-20,000 pg/mL

N-acetylcysteine

Dog

Plasma

LC/MS/MS

EDTA

0.025 mL

1-1,000 µg/mL

Yes

N-acetylcysteine

Rabbit

Plasma

LC/MS/MS

EDTA

0.025 mL

1-1,000 µg/mL

Yes

Nalbuphine

Human

Plasma

LC/MS/MS

Heparin

0.25 mL

0.1-50 ng/mL

Naloxone

Human

Plasma

LC/MS/MS

Heparin

0.25 mL

0.1-50 ng/mL

Naproxen

Human

Plasma

LC/MS/MS

Heparin

0.025 mL

0.100-100 µg/mL

Yes

Nifuratel

Human

Plasma

LC/MS/MS

Heparin

0.1 mL

1.00 - 200 ng/mL

Nintedanib

Human

Plasma

LC/MS/MS

EDTA

0.05 mL

0.0500 - 50.0 ng/mL

Yes

Nitedanib Carboxylic aicd

Human

Plasma

LC/MS/MS

EDTA

0.05 mL

0.0500 - 50.0 ng/mL

Yes

Norethindrone

Human

Plasma

LC/MS/MS

Heparin

0.25 mL

20-10,000 pg/mL

Yes

Norflaxacin

Human

Plasma

LC/MS/MS

EDTA

0.1 mL

10.0 - 1,000 ng/mL

Yes

Norgestrel
17-deacetylnorgestimate

Human

Plasma

LC/MS/MS

Heparin

0.25 mL

40-20,000 pg/mL
20-10,000 pg/mL

Yes

Omeprazole

Human

Plasma

LC/MS/MS

EDTA

0.05 mL

1.00 - 1,000 ng/mL

Yes

Omeprazole sulfone

Human

Plasma

LC/MS/MS

EDTA

0.05 mL

0.500 - 500 ng/mL

Yes

Ondansetron

Human

Plasma

LC/MS/MS

Heparin

0.05 mL

0.5-250 ng/mL

Yes

Oxybutynin

Human

Plasma

LC/MS/MS

Heparin

0.4 mL

0.0500 - 25.0 ng/mL

Yes

Oxycodone

Human

Plasma

LC/MS/MS

EDTA or Heparin

0.1 mL

0.2-50 ng/mL

Yes

Oxycodone
Oxymorphone
Noroxycodone

Human

Plasma

LC/MS/MS

Heparin

0.5 mL

0.05-25 ng/mL

Yes

Oxypurinol

Human

Serum

LC/MS/MS

N/A

0.025 mL

0.100 - 20.0 ug/mL

Yes

Paclitaxel

Human

Plasma

LC/MS/MS

EDTA or Heparin

0.1 mL

0.5-200 ng/mL

Pioglitazone

Human

Plasma

LC/MS/MS

EDTA

0.05 mL

1.00 - 1,000 ng/mL

Yes

Piperacillin

Human

Plasma

LC/MS/MS

Heparin

0.025 mL

0.0500 - 50.0 ug/mL

Piperacillin

Human

ELF

LC/MS/MS

N/A

0.8 mL

1.00 - 500 ng/mL

Prednisolone

Human

Plasma

LC/MS/MS

Heparin

0.1 mL

1.00 - 1,000 ng/mL

Yes

Prednisone

Human

Plasma

LC/MS/MS

Heparin

0.1 mL

1.00 - 1,000 ng/mL

Yes

Prilocaine

Human

Plasma

LC/MS/MS

EDTA

0.05 mL

0.2-100 ng/mL

Promethazine

Human

Plasma

LC/MS/MS

Heparin

0.1 mL

0.2-100 ng/mL

Quetiapine

Human

Plasma

LC/MS/MS

EDTA or Heparin

0.05 mL

1-1,000 ng/mL

Yes

Repaglinide

Human

Plasma

LC/MS/MS

EDTA

0.05 mL

0.1-100 ng/mL

Yes

Repaglinide

Human

Plasma

LC/MS/MS

EDTA

0.05 mL

0.100 - 100 ng/mL

Yes

Repaglinide

Human

Plasma

LC/MS/MS

Heparin

0.2 mL

0.100 - 100 ng/mL

Yes

Ribavirin

Human

Plasma

LC/MS/MS

Heparin

0.05 mL

5.00 - 2,500 ng/mL

Yes

Riboflavin
Riboflavin 5-phosphate

Dog

Plasma

Fluorescence

Heparin

0.05 mL

20-10,000 ng/mL
40-20,000 ng/mL

Riboflavin
Riboflavin 5-phosphate

Rat

Plasma

Fluorescence

Heparin

0.05 mL

20-10,000 ng/mL
40-20,000 ng/mL

Rifampin
25-desacetylrifampin

Human

Plasma

LC/MS/MS

EDTA

0.05 mL

0.1-20 µg/mL

Yes

Rifaximin

Human

Plasma

LC/MS/MS

Heparin

0.05 mL

0.100 - 25.0 ng/mL

Yes

Rifaximin

Human

Urine

LC/MS/MS

N/A

0.5 mL

0.200 - 100 ng/mL

Yes

Riluzole

Human

Serum

LC/MS/MS

N/A

0.1 mL

1-500 ng/mL

Risperidone
9- hydroxyrisperidone

Human

Plasma

LC/MS/MS

Heparin

0.05 mL

0.1-100 ng/mL

Yes

Ropivacaine

Human

Plasma

LC/MS/MS

Heparin

0.02 mL

1.00 - 1,000 ng/mL

Yes

Rosuvastatin
n-desmethyl rosuvastatin

Human

Plasma

LC/MS/MS

Heparin

0.1 mL

0.1-50 ng/mL

Yes

Simvastatin
Simvastatin hydroxy acid

Human

Plasma

LC/MS/MS

Heparin

0.25 mL

0.05-50 ng/mL

Yes

Sitagliptin

Human

Plasma

LC/MS/MS

Heparin

0.2 mL

0.500 - 1,000 ng/mL

Yes

Sorafenib

Human

Plasma

LC/MS/MS

EDTA

0.05 mL

10-10,000 ng/mL

Yes

Sumatriptan

Human

Plasma

LC/MS/MS

Heparin

0.1 mL

1-200 ng/mL

Tazobactam

Human

Plasma

LC/MS/MS

Heparin

0.02 mL

0.100 - 60.0 ug/mL

Tazobactam

Human

ELF

LC/MS/MS

N/A

0.02 mL

1.00 - 250 ng/mL

Tazobactam M1

Human

Plasma

LC/MS/MS

Heparin

0.02 mL

0.0500 - 30.0 ug/mL

Tenofovir

Human

Plasma

LC/MS/MS

Heparin

0.1 mL

2.00 - 1,000 ng/mL

Yes

Tolbutamide

Human

Plasma

LC/MS/MS

EDTA

0.1 mL

0.1-20 µg/mL

Tolbutamide

Human

Plasma

LC/MS/MS

EDTA

0.02 mL

100 - 50,000 ng/mL

Yes

Tolbutamide
4-hydroxytolbutamide

Human

Urine

LC/MS/MS

N/A

0.1 mL

0.1-20 µg/mL

Trazodone

Human

Plasma

LC/MS/MS

Heparin

0.05 mL

0.2-200 ng/mL

Yes

Tretinoin

Human

Plasma

LC/MS/MS

EDTA

0.2 mL

0.4-10 ng/mL

Yes

Trimetazidine

Human

Plasma

LC/MS/MS

Heparin

0.2 mL

0.200 - 100 ng/mL

Yes

Urea

Human

Plasma

Colorimetric

EDTA

0.01 mL

2.50 - 50.0 mg/dL

N/A

Urea

Human

ELF

Colorimetric

N/A

0.3 mL

0.0500 - 1.00 mg/dL

N/A

Valerenic acid
Hydroxyvalerenic acid
Acetoxyvalerenic acid

Human

Plasma

LC/MS/MS

Heparin

0.2 mL

1-500 ng/mL

Vancomycin

Human

Plasma

LC/MS/MS

Heparin

0.02 mL

50-25,000 ng/mL

Vidagliptin

Human

Plasma

LC/MS/MS

Heparin

0.2 mL

0.500 - 500 ng/mL

Yes

Voruciclib

Human

Plasma

LC/MS/MS

EDTA

0.1 mL

5.00 - 2,000 ng/mL

Yes

Warfarin (R-)

Human

Plasma

LC/MS/MS

Heparin

0.025 mL

2-2,000 ng/mL

Yes

Warfarin (S-)

Human

Plasma

LC/MS/MS

Heparin

0.025 mL

2-2,000 ng/mL

Yes

Yohimbine

Human

Plasma

LC/MS/MS

EDTA

0.1 mL

0.1-50 ng/mL

Zolpidem

Human

Plasma

LC/MS/MS

EDTA

0.05 mL

1-150 ng/mL

Yes

Zolpidem

Baboon

Plasma

LC/MS/MS

EDTA

0.05 mL

1-1,000 ng/mL

Yes

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