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Biomarker: KC-GRO

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Analyte:

KC-GRO

Platform:

Matrix:

Mouse Serum

Status:

Experienced Running

Required Sample Volume:

25 µL/well

Sensitivity-LLOQ/ULOQ:

LLOQ: 1.98 pg/mL
ULOQ: 7,200 pg/mL

Biological or Clinical Significance:

Mouse KC (KC/GRO)—also known as CXCL1, GROα, neutrophil-activating protein 3 (NAP-3), and melanoma growth stimulating activity alpha (MGSA-α)—is a 10.2 kDa CXC chemokine. KC/GRO is produced by fibroblasts induced by platelet-derived growth factor and expressed in macrophages and endothelial cells. It produces a biological signal by binding to its receptor, CXCR2. During inflammation, it is involved in neutrophil activation and shows hematopoietic activity. Upon secretion from bone marrow stromal cells through proteolytic cleavage, the N-terminal processed form of KC (5-72) shows highly enhanced hematopoietic activity. This chemokine and its receptor are responsible for neutrophil chemotaxis in epidemic keratoconjunctivits.The Mouse KC/GRO Kit provides assay-specific components for the quantitative determination of endogenous KC/GRO in mouse urine, serum, plasma, and cell culture supernatants.

References:

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