72 kDa type IV collagenase, also known as matrix metalloproteinase-2 (MMP-2), is an enzyme that in humans is encoded by the MMP2 gene. Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix (ECM) in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis.

Mutations in the MMP2 gene are associated with Torg-Winchester syndrome, multicentric osteolysis, arthritis syndrome,[4] and possibly keloids.