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Biomarker:

sIL-4R

Biological or Clinical Significance:

sIL-4R is a receptor for both interleukin 4 and interleukin 13, and it couples to the JAK1/2/3-STAT6 pathway. The IL4 response is involved in promoting Th2 differentiation. The IL4/IL13 responses are involved in regulating IgE production and, chemokine and mucus production at sites of allergic inflammation. In certain cell types, can signal through activation of insulin receptor substrates, IRS1/IRS2.

References:

  • IL4R.” (n.d.): n. pag. The Human Protein Atlas. Web.  

Analyte:

sIL-4R

Matrix:

Human Serum

Status:

Experienced Running

Sensitivity-LLOQ:

244 pg/mL

Sensitivity-ULOQ:

62,500 pg/mL

platform

Luminex

Required Sample Volume

50 µL/well

Disease State:

MSD Panel:

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