Gyrolab: the Gyros Platform for Nanoliter-Scale Immunoassays
Platforms

Gyrolab

Fast Assay Results for Nanoliter-Scale Immunoassays

BioAgilytix uses the cutting-edge Gyros platform to analyze immunoassays on a nanoliter scale, generating high-quality data from small volumes of precious sample. Gyrolab automates finely controlled immunoassays in identical microfluidic channels using highly sensitive, laser-induced fluorescence (LIF) detection.

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gyrolab platform analytical device


How the Gyrolab Platform Works

Gyrolab xP uses proprietary Gyrolab CD technology, which is engineered with highly reproducible nanoliter microfluidics for development of robust, nanoliter-scale immunoassays exhibiting broad dynamic ranges. Within each CD itself, a volume definition chamber delivers ultra-accurate sample volumes, with hydrophobic breaks to ensure consistency in volume delivery. An overflow channel eliminates the need for manual pipetting accuracy, and a 15-nl affinity capture column mitigates non-specific binding.

Once CDs are loaded into the Gyrolab workstation – up to 5 discs in a series – the platform performs parallel sample processing via high-sensitivity, laser-induced fluorescence detection. The CDs are spun at controlled speeds to ensure optimal binding and uniform conditions for all assays. This is possible through a precise, automated control of centrifugal and capillary forces, which steer liquid flow through nanoliter-scale microfluidic structures contained within the CD.

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bioagilytix platform comparison guide

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Ideal Gyrolab Applications: For Nanoliter-Scale Immunoassays

The flexibility of Gyros’ technology makes it a viable platform for any phase of biologic development. In the discovery stage, development is subject to aggressive timelines, and large and diverse sample numbers must be analyzed – typically with limited sample and reagent volumes. For such projects, Gyrolab enables serial sampling on reduced volumes, with rapid time to results. In comparison, for regulated bioanalysis Gyrolab’s automation increases method robustness and shortens project timelines by yielding high-quality data for fast decision-making.

Overall, the Gyros platform is very valuable when used in studies that use small sample volumes but require frequent sampling, and for a range of complex matrices such as serum and cell culture. The BioAgilytix team uses our Gyrolab xP workstations most commonly to support our work with biomarkers, pharmacokinetics (PK), and lot release testing, but we are have the expertise to tailor the platform to meet your unique assay specifications.

biomarkers

Biomarkers

pharmacokinetics

Pharmacokinetics


Key Gyros Benefits: High Precision and Fast Total Assay Time

By significantly reducing sample and reagent consumption, Gyrolab removes time- and cost-consuming roadblocks faced with limited sample availability in more traditional methods. The platform’s ability to automate assay workflows also mitigates variability that may otherwise occur during manual sample and reagent loading, and yields rapid but accurate results for fast, effective decision-making. The technology behind the Gyros platform also minimizes dilutions and assay repeats by reproducibly measuring concentration over a broad dynamic range.

There is little need for sample pretreatment, and assays can be run in a broad range of matrices. This flexibility extends to assay formats – Gyrolab CDs provide a foundation on which to design assays to quantify any protein with a suitable binding pair.

gyrolab analysis report

Top Benefits of Gyrolab Assays:

  • High Sensitivity
  • High Precision
  • Wide Dynamic Range
  • Reduced Matrix Interference
  • Robust and Rugged
  • Fast Total Assay Time
  • Adaptability to Automation
  • Reduced Sample Size
gyrolab platform article

Gyrolab In Action:

Development and validation of an alpha fetoprotein immunoassay using Gyros technology

This article describes the development of a method for AFP using the Gyrolab.

View the Article


Bioagilytix’s Gyrolab Platform Expertise

When your immunoassay needs high precision at high throughput, and timelines are critical, BioAgilytix makes Gyrolab our go-to technology. Its flow-through affinity column format minimizes matrix interference at nanoliter volumes, to deliver precise results with greatly reduced sample volume requirements. We know how to leverage Gyros’ platform innovation to make the most of your precious sample volumes, and can quickly develop the assays we need to deliver fast, efficient, and reliable results.

Collaborate with our scientific team and we’ll help you determine how to best take advantage of Gyrolab’s capabilities.

scientist performing gyrolab assay


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