BioAgilytix uses the cutting-edge Gyros platform to analyze immunoassays on a nanoliter scale, generating high-quality data from small volumes of precious sample. Gyrolab automates finely controlled immunoassays in identical microfluidic channels using highly sensitive, laser-induced fluorescence (LIF) detection.
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Gyrolab xP uses proprietary Gyrolab CD technology, which is engineered with highly reproducible nanoliter microfluidics for development of robust, nanoliter-scale immunoassays exhibiting broad dynamic ranges. Within each CD itself, a volume definition chamber delivers ultra-accurate sample volumes, with hydrophobic breaks to ensure consistency in volume delivery. An overflow channel eliminates the need for manual pipetting accuracy, and a 15-nl affinity capture column mitigates non-specific binding.
Once CDs are loaded into the Gyrolab workstation – up to 5 discs in a series – the platform performs parallel sample processing via high-sensitivity, laser-induced fluorescence detection. The CDs are spun at controlled speeds to ensure optimal binding and uniform conditions for all assays. This is possible through a precise, automated control of centrifugal and capillary forces, which steer liquid flow through nanoliter-scale microfluidic structures contained within the CD.
The flexibility of Gyros’ technology makes it a viable platform for any phase of biologic development. In the discovery stage, development is subject to aggressive timelines, and large and diverse sample numbers must be analyzed – typically with limited sample and reagent volumes. For such projects, Gyrolab enables serial sampling on reduced volumes, with rapid time to results. In comparison, for regulated bioanalysis Gyrolab’s automation increases method robustness and shortens project timelines by yielding high-quality data for fast decision-making.
Overall, the Gyros platform is very valuable when used in studies that use small sample volumes but require frequent sampling, and for a range of complex matrices such as serum and cell culture. The BioAgilytix team uses our Gyrolab xP workstations most commonly to support our work with biomarkers, pharmacokinetics (PK), and lot release testing, but we are have the expertise to tailor the platform to meet your unique assay specifications.
When your immunoassay needs high precision at high throughput, and timelines are critical, BioAgilytix makes Gyrolab our go-to technology. Its flow-through affinity column format minimizes matrix interference at nanoliter volumes, to deliver precise results with greatly reduced sample volume requirements. We know how to leverage Gyros’ platform innovation to make the most of your precious sample volumes, and can quickly develop the assays we need to deliver fast, efficient, and reliable results.
Collaborate with our scientific team and we’ll help you determine how to best take advantage of Gyrolab’s capabilities.