Cutaneous T-cell attracting chemokine (CTACK/CCL27) is a small chemotactic cytokine belonging to the CC family of chemokines which has well-appreciated roles in adhesion and directional homing of immune and inflammatory cells. It is pivotal in mediating the migration of lymphocytes into the skin by binding to the chemokine receptor CCR10. CTACK is predominantly and continuously expressed in the skin by keratinocytes and is highly upregulated in wounds and in inflammatory diseases like atopic dermatitis and psoriasis. Studies have shown that CTACK-CCR10 interaction directly regulates T-cell recruitment to inflamed skin and is the likely key regulator of basal T-cell trafficking during immunosurveillance.